Heart attacks & blood flow

Jerry Wayne Decker ( jwdatwork@yahoo.com )
Thu, 16 Sep 1999 14:44:26 -0700 (PDT)

Hi Folks!

A friend's mother recently went into the hospital from
a heart attack so I was telling her about some useful
info that MIGHT be of interest;

Linus Paulings' patented discovery that you can do for
yourself...if the pharmaceutical companies can't make
money from it, you won't hear about it, as much detail
as we have is here;

http://www.keelynet.com/biology/plaque.htm

This is claimed to be a means to thin the blood and
keep the arteries clean;

http://www.keelynet.com/biology/heartcur.txt

and here is a repost that I couldn't get the URL to
work on so I'm having to quote the article;

http://www2.beverageonline.com/welcome/ngck

Circulation Article Reports Ways Purple Grape Juice
may Fight Narrowing of the Arteries

- Clinician Cites Effect of the Juice in Study on
Contributors to Coronary Artery Disease --

CONCORD, Mass., Sept. 7 /PRNewswire/ -- Researchers
from the University of Wisconsin Medical School have
identified ways in which drinking purple grape juice
may fight atherosclerosis, or narrowing of the
arteries, according to a study in the September 7th
issue of Circulation, a journal published by the
American Heart Association.

The study showed that when fifteen subjects, all
people with coronary artery disease, drank purple
grape juice for two weeks, the elasticity of their
blood vessels significantly increased and the rate at
which their LDL cholesterol oxidized significantly
decreased.

'This is of great interest,' notes John Folts, Ph.D.,
'because it suggests that consuming purple grape juice
could positively effect the atherosclerotic process in
several important ways. Previously, much of the
potential benefit of consuming purple grape juice was
attributed to its apparent ability to make the blood
less likely to clot. Now we see that there appear to
be two other beneficial factors at work as well.'

Dr. Folts, the senior author of the study and director
of the Coronary Thrombosis Research and Prevention
Laboratory at the University of Wisconsin Medical
School, has conducted extensive research in this area,
with much of his previous work focusing on the ability
of grape products to reduce the stickiness of blood
platelets.

'There are a number of primary contributors to
atherosclerosis,' explains Folts, 'Three of them are
the stickiness of our blood, the reduced flexibility
of our arteries, and the speed at which we oxidize LDL
cholesterol. In previous studies, we saw that
drinking purple grape juice reduced blood stickiness.
What this study suggests is that drinking the juice
has a beneficial effect on two other primary
contributors as well.'

Vasodilation

The ability of the blood vessels to expand in response
to increased blood flow and thus deliver more oxygen
where it's needed is called flow-mediated
vasodilation.
It is indicative of the health of the endothelium --
the layer of cells which lines the interior wall of
all the blood vessels in the body. When the
endothelium is impaired, such as in people with
existing coronary artery disease, blood vessels are
less able to respond to the sudden need for increased
blood flow. They are also more susceptible to
atherosclerosis, or narrowing of the arteries, and
blood clot formation.

When blood clots in a narrowed artery, a heart attack
or stroke may occur.

People with existing coronary artery disease typically
have impaired endothelial function.

The study looked at fifteen men and women (average age
62.5 plus or minus 12.7) with coronary artery disease.

Each person drank approximately 7 cc/kg/day of the
juice for 14 days. Flow mediated vasodilation -- the
ability of the arteries to expand in response to
increased flow of blood -- was measured at baseline as
2.2mm plus or minus 2.9%.

After the juice was consumed for 14 days, flow
mediated dilation was measured again and found to be
6.4mm plus or minus 4.7% (p= 0.003), resulting in a
mean change of 4.2mm plus or minus 2.9% (p<0.001) --
almost triple the previous ability of the blood
vessels to respond to increased blood flow.

LDL Oxidation Rates

In studying LDL oxidation, blood samples were drawn
and LDL oxidation lag time was measured for each
subject at the beginning of the study and then again
at its conclusion. Lag time measurement is a commonly
used method for determining how long it takes for
cholesterol to oxidize when exposed to certain oxidant
chemicals.

The longer the lag time, the slower the onset of LDL
oxidation. The slower the onset of oxidation, the less
likely that oxidation will contribute to
atherosclerosis, since oxidized cholesterol
contributes to the build-up of plaque in the arteries.

Among the entire group, the lag time improved by 34.5%
(p= 0.015). At the beginning of the study the average
lag time was 87 minutes (plus or minus 29 minutes).

After the juice was consumed for 14 days, lag time was
measured again. After the juice, average lag time
improved to 117 minutes (plus or minus 23 minutes).

Eleven patients in the study were consuming vitamin E
(400IU/day). For them, the initial lag time was 86
minutes (plus or minus 33 minutes); after drinking the
juice it improved to 121 minutes (plus or minus 24
minutes).

'People with excellent cardiovascular health usually
have healthy endothelial function, a slow onset of LDL
oxidation and moderate blood platelet activity,' notes
Folts.

'This study suggests that drinking purple grape juice
may promote these heart healthy mechanisms. Combined
with what we have learned from previous studies on
grape juice's ability to decrease platelet activity,
it makes sense to include daily consumption of purple
grape juice as part of a diet high in fruits and
vegetables and low in saturated fat.'

Welch's Purple 100% Grape Juice has been certified by
the American Heart Association for its HeartCheck
program. The study was underwritten, in part, by the
Oscar Rennenbohm Foundation, Madison, WI; the Nutricia
Research Foundation, The Netherlands; and Welch Foods
Inc., A Cooperative, Concord, MA.

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Please respond to jdecker@keelynet.com
as I am writing from my work email of
jwdatwork@yahoo.com.........thanks!
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