Thrombocytopenia purpura & vaccination
http://www.emedicine.com/EMERG/topic579.htm
Deficiency of blood platelets
ITP resolves spontaneously only on rare occasions. In ITP, the autoantibodies are directed against platelets. Platelets are minute, disk-shaped components of the blood that are needed for prevention and control of bleeding. Platelets are formed in the bone marrow and are released into the blood. Platelets have a limited life span before they are replaced by new platelets. In ITP, the platelets are prematurely destroyed. In extreme cases, the spleen may have to be removed or a blood transfusion given.
[Media UK, Feb 2001, MMR--idiopathic thrombocytopenic purpura (ITP)] New concern over MMR
Corri Black, James A. Kaye, Hershel Jick. January 2003. MMR vaccine and idiopathic thrombocytopaenic purpura
[2009 Feb] How Important is Hepatitis B Vaccination at Birth? By Deanna Gromowski Ian was given his Hepatitis B vaccination on July 1st, 2007 even though he was fighting off the meconium, even though he had a fever ABOVE 100 degrees on June 30th, and even though he had a fever above 100 degrees the day of July 1st they STILL VACCINATED HIM...... Within 12 hours of his vaccination he had the rash, within 24 hours the severe thrombocytopenia set in, and then he was in a fatal state from then on. NO DOCTORS, NURSES, STAFF would even consider the vaccination as the source.
Autret E, et al. [Thrombocytopenic purpura after isolated or combined vaccination against measles, mumps and rubella]. Therapie. 1996 Nov-Dec;51(6):677-80. French. PMID: 9164004; UI: 97306737.
Azeemuddin S Thrombocytopenia purpura after combined vaccine against measles, mumps, and rubella. Clin Pediatr (Phila). 1987 Jun;26(6):318. No abstract available. PMID: 3581644; UI: 87216801.
Bartos
HR. Thrombocytopenia associated with rubella vaccination. N Y State J Med. 1972
Feb 15;72(4):499. No abstract available.PMID: 4501388; UI: 72119111
Casoli
P, et al. [Acute idiopathic thrombocytopenic purpura after
anti-influenza vaccination]. Medicina (Firenze). 1989 Oct-Dec;9(4):417-8. Italian. PMID:
2634230; UI: 90231074.
Chang SK, Farrell DL, Dougan K, Kobayashi B. Acute idiopathic thrombocytopenic purpura following combined vaccination against measles, mumps, and rubella. J Am Board Fam Pract. 1996 Jan-Feb;9(1):53-5. No abstract available. PMID: 8770810 UI: 96366633.
Cummins
D, Wilson ME, Foulger KJ, Dawson D, Hogarth AM. Haematological
changes associated with influenza vaccination in people aged over 65: case report and
prospective study. Clin Lab Haematol. 1998 Oct;20(5):285-7.PMID:
9807675 [PubMed - indexed for MEDLINE]
Blood count abnormalities are a recognized feature of many viral infections
and immunizations but little is known about the haematological effects of influenza
vaccination. We report a 67-year-old patient who developed thrombocytopenia and
severe neutropenia 3 weeks after she was vaccinated against influenza. The case
led us to study prospectively the blood counts of 70 people aged over 65 before and after
they received influenza vaccine. There were no significant changes in the levels of
haemoglobin, neutrophils, monocytes, eosinophils or platelets after vaccination, but the
total WBC counts (mean +/- SD, 6.86 +/- 1.52) and lymphocyte counts (1.69 +/- 0.61) were
significantly lower at 4 weeks than at baseline (7.22 +/- 1.60 [P = 0.02] and 1.86 +/-
0.62 [P = 0.001] respectively) and in four subjects the lymphocyte count fell to below 0.7
x 10(9)/l. Since influenza vaccine does not contain live virus, its haematological effects
presumably relate to the host immune response rather than to viral replication.
Drachtman
RA, et al. Exacerbation of chronic idiopathic thrombocytopenic
purpura following measles-mumps-rubella immunization. Arch Pediatr Adolesc Med. 1994
Mar;148(3):326-7. No abstract available.PMID: 8130872; UI: 94177263.
Jonville-Bera
AP, et al Thrombocytopenic purpura after measles, mumps and rubella vaccination: a
retrospective survey by the French regional pharmacovigilance centres and pasteur-merieux
serums et vaccins. Pediatr Infect Dis J. 1996 Jan;15(1):44-8. PMID: 8684875; UI: 6274272.
Neau
D, Bonnet F, Michaud M, Perel Y, Longy-Boursier M, Ragnaud JM, Guillard JM.
Immune thrombocytopenic purpura after recombinant hepatitis B vaccine:
retrospective study of seven cases.Scand J Infect Dis.
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Neiderud
J. Thrombocytopenic purpura after a combined vaccine against morbilli, parotitis
and rubella. Acta Paediatr Scand. 1983 Jul;72(4):613-4. No abstract available.PMID:
6684869; UI: 84020310.
Ronchi F, Cecchi P, Falcioni F, Marsciani A, Minak G, Muratori G, Tazzari PL, Beverini S. Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine. Arch Dis Child. 1998 Mar;78(3):273-4. PMID: 9613364 [PubMed - indexed for MEDLINE]
Rejjal
AL, et al. Thrombocytopenic purpura following measles-mumps-rubella
vaccination. Ann Trop Paediatr. 1993;13(1):103-4. No abstract available.PMID: 7681639; UI:
93213086.
Wiersbitzky
S, et al. Postvaccinal thrombocytopenia: fact or myth? Pediatr Hematol
Oncol. 1995 Sep-Oct;12(5):503-5. No abstract available.PMID: 8519638; UI: 96093262.
Wiersbitzky
S, et al. [Thrombocytopenic purpura following immunization
with a live vaccine (mumps-measles-rubella vaccination)]? Kinderarztl Prax. 1992
Feb;60(1):28-9. German. No abstract available.
PMID: 1556850; UI: 92211905.
Vlacha
V, et al. Recurrent thrombocytopenic purpura after repeated
measles-mumps-rubella vaccination. Pediatrics. 1996 May;97(5):738-9. No abstract
available.PMID: 8628619; UI: 96206314.