Hepatitis B vaccine adverse events: citations
Hepatitis vaccination

[2008] Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years This study found statistically significant evidence to suggest that boys in United States who were vaccinated with the triple series Hepatitis B vaccine, during the time period in which vaccines were manufactured with thimerosal, were more susceptible to developmental disability than were unvaccinated boys.

[2008 Sept] Carolyn Gallagher a; Melody Goodman a. Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years  This study found statistically significant evidence to suggest that boys in United States who were vaccinated with the triple series Hepatitis B vaccine, during the time period in which vaccines were manufactured with thimerosal, were more susceptible to developmental disability than were unvaccinated boys.

Neonatal Deaths After Hepatitis B Vaccine   The Vaccine Adverse Event Reporting System, 1991-1998   Manette T. Niu, MD; Marcel E. Salive, MD, MPH; Susan S. Ellenberg, PhD

Allergy reactions to gelatin & neomycin (journal articles)

Ajithkumar K, et al. [See Related Articles] Vaccine-induced necrobiotic granuloma. Clin Exp Dermatol. 1998 Sep;23(5):222-4. PMID: 10233605; UI: 99332212. We report two cases of necrobiotic palisaded granulomas which developed at the site of intradermal hepatitis B vaccination. To the best of our knowledge, this kind of reaction has not been reported previously.
Arya SC.    Ophthalmic complications of vaccines against hepatitis B virus. Int Ophthalmol. 1997;21(3):177-8. No abstract available.PMID: 9587836; UI: 98249417.
Albitar S, et al.     Bilateral retrobulbar optic neuritis with hepatitis B vaccination. Nephrol Dial Transplant. 1997 Oct;12(10):2169-70. No abstract available.PMID: 9351086; UI: 98012356.

Allen MB, et al.    Pulmonary and cutaneous vasculitis following hepatitis B vaccination. Thorax. 1993 May;48(5):580-1. No abstract available.PMID: 8322254; UI: 93310736.

Baglivo E, et al.      Multiple evanescent white dot syndrome after hepatitis B vaccine. Am J Ophthalmol. 1996 Sep;122(3):431-2. PMID: 8794720; UI: 96387180.
Ballinger AB, et al.  Severe acute hepatitis B infection after vaccination. Lancet. 1994 Nov 5;344(8932):1292. No abstract available.PMID: 7734013; UI: 95057571.     
Bardazzi F, et al. [See Related Articles] Graham Little-Piccardi-Lasseur syndrome following HBV vaccination. Acta Derm Venereol. 1999 Jan;79(1):93. No abstract available.PMID: 10086877; UI: 99184681.
Bensaid J, et al. [See Related Articles] [Benign acute pericarditis after vaccination against hepatitis B]. Presse Med. 1993 Feb 20;22(6):269. French. No abstract available.PMID: 8511146; UI: 93288675.

Berkman N, et al.  [Bilateral neuro-papillitis after hepatitis B vaccination]. Presse Med. 1996 Sep 28;25(28):1301. French. No abstract available.PMID: 8949792; UI: 97107044        

Berkman N.  [A case of segmentary unilateral occlusion of the central retinal vein following hepatitis B vaccination]. Presse Med. 1997 Apr 26;26(14):670. French. No abstract available.PMID: 9180888; UI: 97324783.
Bentsi-Enchill A. Adverse events following the administration of hepatitis B vaccines. Can Commun Dis Rep. 1992 Apr 17;18(7):49-53. English; French. No abstract available.PMID: 1291014; UI: 93177423.

Birley HD, et al. [See Related Articles] Hepatitis B immunisation and reactive arthritis. BMJ. 1994 Dec 3;309(6967):1514. No abstract available.PMID: 7804071; UI: 95102378.
Brezin A, et al. [See Related Articles] Visual loss and eosinophilia after recombinant hepatitis B vaccine. Lancet. 1993 Aug 28;342(8870):563-4. No abstract available.PMID: 8102709; UI: 93360669.

Biasi D, et al.  A new case of reactive arthritis after hepatitis B vaccination. Clin Exp Rheumatol. 1993 Mar-Apr;11(2):215. No abstract available.PMID: 8508565; UI: 93284771.
Biasi D, et al.[Rheumatological manifestations following hepatitis B vaccination. A report of 2 clinical cases]. Recenti Prog Med. 1994 Sep;85(9):438-40. Review. Italian. PMID: 7938876; UI: 95025084.    
Biacabe B, et al. A case report of fluctuant sensorineural hearing loss after hepatitis B vaccination. Auris Nasus Larynx. 1997 Oct;24(4):357-60. PMID: 9352826; UI: 98012875.
Bourges JL, et al.   [Multifocal placoid epitheliopathy and anti-hepatitis B vaccination]. J Fr Ophtalmol. 1998 Nov;21(9):696-700. French. PMID: 9894208; UI: 99111579.    
Bonfils P, et al.   [Fluctuant perception hearing loss after hepatitis B vaccine]. Ann Otolaryngol Chir Cervicofac. 1996;113(6):359-61. French. PMID: 9124778; UI: 97254004.

Brooks R, et al.   Guillain-Barre syndrome following trivalent influenza vaccine in an elderly patient. Mt Sinai J Med. 1980 Mar-Apr;47(2):190-1. No abstract available.PMID: 6967162; UI: 80232515       

Bracci M, et al.    Polyarthritis associated with hepatitis B vaccination. Br J Rheumatol. 1997 Feb;36(2):300-1. No abstract available.PMID: 9133957; UI: 97279516     

Brezin A, et al.    Visual loss and eosinophilia after recombinant hepatitis B vaccine. Lancet. 1993 Aug 28;342(8870):563-4. No abstract available.PMID: 8102709; UI: 93360669.
Bui-Quang D, et al. [Cutaneous vasculitis after hepatitis B vaccination with recombinant vaccine in a renal transplant patient]. Presse Med. 1998 Sep 12;27(26):1321-3. French. PMID: 9779046; UI: 98452068.
Christau B, et al.  [Reactive arthritis following vaccination against hepatitis B]. Ugeskr Laeger. 1987 Jul 6;149(28):1882. Danish. No abstract available.PMID: 3433400; UI: 88128088.        

Campins Marti M, et al.  [Hepatitis B vaccine and multiple sclerosis]. An Esp Pediatr. 1998 Dec;49(6):555-7. Review. Spanish. No abstract available. PMID: 9972614; UI: 99138561.
Carmeli Y, et al. [See Related Articles] Hepatitis B vaccine side-effect. Lancet. 1993 Jan 23;341(8839):250-1. No abstract available.PMID: 8093541; UI: 93125043.
Carmeli Y, et al. [See Related Articles] Serious hepatitis B vaccine adverse reactions, are they immune-mediated? Vaccine. 1993 Oct;11(13):1358-9. No abstract available.PMID: 8296488; UI: 94127088.
Classen JB.   The diabetes epidemic and the hepatitis B vaccines. N Z Med J. 1996 Sep 27;109(1030):366. No abstract available.PMID: 8890866; UI: 97045944.
Cockwell P, et al.   Vasculitis related to hepatitis B vaccine. BMJ. 1990 Dec 1;301(6763):1281. No abstract available.PMID: 2148701; UI: 91105369.      
Creange A, et al.   Lumbosacral acute demyelinating polyneuropathy following hepatitis B vaccination. Autoimmunity. 1999;30(3):143-6. [MEDLINE record in process] PMID: 10520897; UI: 99449207.We report a patient who presented with an acute inflammatory demyelinating polyneuropathy, that followed the second injection of a hepatitis B vaccination, and characterized by motor and sensory deficit restricted to lower limbs and perineum, and persistent bladder dysfunction. The relationship between the preceding event and neurological disease is discussed.  creange@univ-paris12.fr PMID: 10520897, UI: 99449207

Daoud MS, et al.    Anetoderma after hepatitis B immunization in two siblings. J Am Acad Dermatol. 1997 May;36(5 Pt 1):779-80. No abstract available.PMID: 9146542; UI: 97292002       
Delage G, et al. [See Related Articles] [The possible relation between hepatitis B vaccination and chronic fatigue syndrome]. Union Med Can. 1993 Jul-Aug;122(4):278-9. French. No abstract available.PMID: 8367918; UI: 93377302.
Devin F, et al.    Occlusion of central retinal vein after hepatitis B vaccination. Lancet. 1996 Jun 8;347(9015):1626. No abstract available.PMID: 8667894; UI: 96240964.    
Deisenhammer F, et al. Acute cerebellar ataxia after immunisation with recombinant hepatitis B vaccine. Acta Neurol Scand. 1994 Jun;89(6):462-3. PMID: 7976236; UI: 95066735.      
Diego Nunez MA, et al. [See Related Articles] [Vaccination against hepatitis B and multiple sclerosis]. An Esp Pediatr. 1999 Jan;50(1):97. Spanish. No abstract available.PMID: 10083655; UI: 99183224.
 
Dickie AS, et al.    Hepatitis B surface antigenaemia in a child after vaccination. Med J Aust. 1996 Feb 5;164(3):187. No abstract available.PMID: 8628142; UI: 96205691.
Domingo Soriano M, et al.   [Diseases caused by immune complexes associated with hepatitis B virus]. Rev Clin Esp. 1986 Jul;179(3):151-4. Spanish. No abstract available.PMID: 2876464; UI: 87017989     

Erlinger S.  [Vaccination against hepatitis B. Many more advantages than disadvantages]. Presse Med. 1997 Feb 1;26(2):60-1. French. PMID: 9082410; UI: 97226576.        
In particular a few cases of multiple sclerosis have been observed after vaccination. Epidemiological data do not show a higher incidence of multiple sclerosis in vaccinated persons when compared to the general population. Although a causal relationship between vaccination and multiple sclerosis cannot be established on epidemiological grounds, it is reasonable to avoid vaccination in patients with this disease or a familial antecedent of multiple sclerosis. The present universal vaccination strategy aimed at protecting all the population against hepatitis B should not be modified.
 
Evans AA, et al. [See Related Articles] Hepatitis B vaccine and liver problems in U.S. children less than 6 years old. Epidemiology. 1999 Nov;10(6):790-1. No abstract available.PMID: 10535806; UI: 20004464.
Erbagci Z.  Childhood bullous pemphigoid following hepatitis B immunization. J Dermatol. 2002 Dec;29(12):781-5.PMID: 12532044 [PubMed - in process]
Bullous pemphigoid (BP) is an acquired autoimmune bullous disorder which predominantly affects the elderly. It is very rare in children. There are approximately 50 reported cases of childhood BP. Although the cause of childhood BP is unknown, drug intake and vaccination have been incriminated in some cases. A total of 13 patients with BP (10 adults and 3 infants) have been described to be related to various vaccines and tetanus toxoid booster. However, no case related to hepatitis B vaccination has previously been reported. Our case of childhood BP developed one week after hepatitis B immunization in a Turkish caucasian child. This case suggests that the hepatitis B surface antigen can function as the triggering factor for BP by inducing a nonspecific immune reactivation which unmasks subclinical BP or by stimulating a specific antibody production that may cross-react with BP antigens.  PMID: 12532044
Fenner W. [See Related Articles] [Hepatitis B vaccination and AIDS]. Niedersachs Zahnarztebl. 1984 Feb;19(2):74. German. No abstract available.PMID: 6587315; UI: 84221307.
Ferrando MF, et al.    Lichen planus following hepatitis B vaccination. Br J Dermatol. 1998 Aug;139(2):350. No abstract available.PMID: 9767265; UI: 99068978.
Fernandez-Funez A, et al.  [Juvenile dermatomyositis concomitant with hepatitis B vaccination]. Med Clin (Barc). 1998 Nov 21;111(17):675. Spanish. No abstract available.PMID: 9881353; UI: 99098028.
Fisher MA, et al.   Hepatitis B vaccine and liver problems in U.S. children less than 6 years old, 1993 and 1994. Epidemiology. 1999 May;10(3):337-9. PMID: 10230847; UI: 99245878      
Fong KS, et al.  Multiple evanescent white dot syndrome--an uncommon cause for an enlarged blind spot. Ann Acad Med Singapore. 1996 Nov;25(6):866-8. Review. PMID: 9055018; UI: 97207761.
Fraser PA, et al. [See Related Articles] Reiter's syndrome attributed to hepatitis B immunisation. BMJ. 1994 Dec 3;309(6967):1513. No abstract available.PMID: 7804068; UI: 95102375.
Fried M, et al.   Uveitis after hepatitis B vaccination. Lancet. 1987 Sep 12;2(8559):631-2. No abstract available.PMID: 2887922; UI: 87314064.

Ganry O, et al.   [Peripheral facial paralysis following vaccination against hepatitis B. Apropos of a case]. Therapie. 1992 Sep-Oct;47(5):437-8. French. No abstract available.PMID: 1299988; UI: 93235177.
Gavaghan T, et al.     Severe systemic vasculitic syndrome post influenza vaccination. Aust N Z J Med. 1993 Apr;23(2):220. No abstract available.PMID: 8517850; UI: 93298120.
Germanaud J, et al. [See Related Articles] A case of severe cytolysis after hepatitis B vaccination. Am J Med. 1995 Jun;98(6):595-6. No abstract available.PMID: 7778577; UI: 95297482.
Gisserot O, et al.  [Lichen planus after hepatitis B vaccination. 3 new cases]. Presse Med. 1997 May 17;26(16):760. French. No abstract available.PMID: 9205473; UI: 97349552.
Goffin E, et al.   Acute hepatitis B infection after vaccination. Lancet. 1995 Jan 28;345(8944):263. No abstract available. PMID: 7823747; UI: 95124110.
Granel B, et al. [See Related Articles] [Occlusion of the central retinal vein after vaccination against viral hepatitis B with recombinant vaccines. 4 cases]. Presse Med. 1997 Feb 1;26(2):62-5. French. PMID: 9082411; UI: 97226577.
Grezard P, et al. [Cutaneous lupus erythematosus and buccal aphthosis after hepatitis B vaccination in a 6-year-old child]. Ann Dermatol Venereol. 1996;123(10):657-9. French. PMID: 9615128; UI: 98277333.
Gross K, et al. Arthritis after hepatitis B vaccination. Report of three cases. Scand J Rheumatol. 1995;24(1):50-2. PMID: 7863281; UI: 95167436.

Green, C et al, "A Case of Hepatitis Related to Etretinate Therapy and Hepatitis B Vaccine", Dermatologica, 1991, 182(2):119-120.

David A Geier, Mark R Geier MD PhD. Chronic adverse reactions associated with hepatitis B vaccination. The Annals of Pharmacotherapy 2002: Vol. 36, No. 12, pp. 1970–1971.
In conclusion, our study demonstrates that adult HBV is statistically associated not only with acute neuropathy, neuritis, myelitis, vasculitis, thrombocytopenia, gastrointestinal disease, multiple sclerosis, and arthritis, but some of these patients go on to develop chronic adverse reactions that persist for at least 1 year following HBV. These types of chronic adverse reactions following adult HBV should be discussed with patients contemplating being immunized with HBV and should be included in the differential diagnosis of those who develop them following adult HBV.

Geier DA, Geier MR.   A one year followup of chronic arthritis following rubella and hepatitis B vaccination based upon analysis of the Vaccine Adverse Events Reporting System (VAERS) database.   Clin Exp Rheumatol 2002 Nov-Dec;20(6):767-71.   MedCon, Inc., Silver Spring, Maryland, USA. mgeier@erols.com

OBJECTIVES: This analysis examined the incidence rate of chronic arthritis adverse reactions reported following adult rubella and hepatitis B vaccinations. In this analysis, etiologic mechanisms for chronic arthritis following adult rubella and hepatitis B vaccines were also explored. METHODS: The Vaccine Adverse Events Reporting System (VAERS) database was analyzed for the incidence rate of reported cases of chronic arthritis in comparison to Tetanus-diphtheria (Td) and tetanus toxoid adult vaccine control groups. RESULTS: Chronic arthritis adverse reactions following adult rubella vaccination were primarily reported in females (female/male ratio = 3.0), at about 45 years-old, and at a mean onset time of 10-11 days following vaccination. Chronic arthritis adverse reactions following adult hepatitis B vaccination were also primarily reported in females(female/male ratio = 3.5), at about 33 years-old, and with a mean onset time of 16 days following vaccination. The incidence rates of chronic arthritis following adult rubella and adult hepatitis B vaccinations were statistically significantly increased, by chi 2 analysis, in comparison to the adult vaccine control groups. The attributable risk of chronic arthritis following adult rubella vaccine ranged from 32 to 53 and from 5.1 to 9.0 following adult hepatitis B vaccine in comparison to the adult vaccine control groups. CONCLUSION: This study revealed that adult rubella and adult hepatitis B vaccines were statistically associated with chronic arthritis which persisted for at least one year. The etiology for these adverse reactions may involve autoimmune mechanisms. Furthermore, potential biases in the reporting rates of adverse reactions to VAERS were not observed.   PMID: 12508767 [PubMed - in process]

Granel B, et al. [Occlusion of the central retinal vein after vaccination against viral hepatitis B with recombinant vaccines. 4 cases]. Presse Med. 1997 Feb 1;26(2):62-5. French. PMID: 9082411; UI: 97226577.       
Grasland A, et al.     [Adult-onset Still's disease after hepatitis A and B vaccination]? Rev Med Interne. 1998 Feb;19(2):134-6. French. PMID: 9775130; UI: 98448256   
Grotto I, et al. Major adverse reactions to yeast-derived hepatitis B vaccines--a review. Vaccine. 1998 Feb;16(4):329-34. Review. PMID: 9607051; UI: 98269934.

Hanzawa S, Takahashi T, Nakayama S, Ohhara K, Ebihara I, Koide H, Ohno J.[A case of membranoproliferative glomerulonephritis associated with hepatitis B (author's transl)]Nippon Jinzo Gakkai Shi. 1980 Jan;22(1):41-9. Japanese. No abstract available.PMID: 7382161 [PubMed - indexed for MEDLINE]
Hall A, Kane M, Roure C, Meheus A. Multiple sclerosis and hepatitis B vaccine? Pubblicato su: Vaccine 1999 Jun 4;17(20-21):2473-5 London School of Hygiene and Tropical Medicine, UK. PMID: 10418891, UI: 99345232
Halsey NA, et al.   Hepatitis B vaccine and central nervous system demyelinating diseases. Viral Hepatitis Prevention Board. Pediatr Infect Dis J. 1999 Jan;18(1):23-4. Review. No abstract available.PMID: 9951975; UI: 99135446.

Heinzlef O, Moguilewski A, Roullet E.[Acute aseptic meningitis after hepatitis B vaccination]Presse Med. 1997 Mar 8;26(7):328. French. No abstract available.PMID: 9122145 [PubMed - indexed for MEDLINE]
Herroelen L, et al.  Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine. Lancet. 1991 Nov 9;338(8776):1174-5. PMID: 1682594; UI: 92047879.
Hutteroth TH, et al. [Aluminum hydroxide granuloma following hepatitis B vaccination]. Dtsch Med Wochenschr. 1990 Mar 23;115(12):476. German. No abstract available.PMID: 2318117; UI: 90200776.
Hassan W, et al.    Reiter's syndrome and reactive arthritis in health care workers after vaccination.  BMJ. 1994 Jul 9;309(6947):94. No abstract available.PMID: 8038674; UI: 94312966.  

Karaali-Savrun F, Altintas A, Saip S, Siva A.  Hepatitis B vaccine related-myelitis?Eur J Neurol. 2001 Nov;8(6):711-5.PMID: 11784358 [PubMed - indexed for MEDLINE]

Kerleau JM, et al.      [Is hepatitis B vaccination a new cause of necrotizing vasculitis]? Rev Med Interne. 1997;18(6):491-2. French. No abstract available.PMID: 9247052; UI: 97390000.

Kakar A, Sethi PK.  Guillain Barre syndrome associated with hepatitis B vaccination.Indian J Pediatr. 1997 Sep-Oct;64(5):710-2. No abstract available.PMID: 10771907 [PubMed - indexed for MEDLINE]

Kear TM, et al.   Transient hepatitis B antigenemia in hemodialysis patients following hepatitis B vaccination. ANNA J. 1996 Jun;23(3):331, 337. No abstract available.PMID: 8716993; UI: 96356647.        [See Related Articles]
Kaplanski G, et al. Central nervous system demyelination after vaccination against hepatitis B and HLA haplotype.  J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):758-9. No abstract available.PMID: 7608688; UI: 95332874.
Korman SH.  Thrombocytopenic purpura during the incubation of hepatitis B. Acta Paediatr Scand. 1991 Oct;80(10):975-6. PMID: 1755310; UI: 92095079         
Kerleau JM, et al.  [Is hepatitis B vaccination a new cause of necrotizing vasculitis]? Rev Med Interne. 1997;18(6):491-2. French. No abstract available.PMID: 9247052; UI: 97390000.        

Konstantinou D, Paschalis C, Maraziotis T, Dimopoulos P, Bassaris H, Skoutelis A. Two episodes of leukoencephalitis associated with recombinant hepatitis B vaccination in a single patient. Clin Infect Dis. 2001 Nov 15;33(10):1772-3.PMID: 11595974 [PubMed - indexed for MEDLINE]

Lasheras Carbajo MD, et al. [See Related Articles] [A case of intense cytolysis following the administration of a hepatitis B vaccine]. Rev Clin Esp. 1999 Jan;199(1):49-50. Review. Spanish. No abstract available.PMID: 10089783; UI: 99189653.

Di Lernia V, et al. [See Related Articles] Erythema multiforme following hepatitis B vaccine. Pediatr Dermatol. 1994 Dec;11(4):363-4. No abstract available.PMID: 7899194; UI: 95207066.
Lilic D, et al. [See Related Articles] Liver dysfunction and DNA antibodies after hepatitis B vaccination. Lancet. 1994 Nov 5;344(8932):1292-3. No abstract available.PMID: 7967997; UI: 95057572.
Lliminana C, et al. [See Related Articles] [Hemolytic anemia and thrombocytopenic purpura after the administration of the recombinant hepatitis B vaccine]. Med Clin (Barc). 1999 Jun 12;113(1):39. Spanish. No abstract available.PMID: 10422080; UI: 99350980.

Le Hello C, et al.   Suspected hepatitis B vaccination related vasculitis. J Rheumatol. 1999 Jan;26(1):191-4. Review. PMID: 9918261; UI: 99114793.
S. Laoussadi, V. Sayag-Boukris, C.-J. Menkes, André Kahan. Department of Rheumatology A, Cochin Hospital, Paris V University, Paris,France. HBV vaccination may induce hypersensitivity and autoimmune reactions in susceptible individuals and healthy
Subjects. Seven patients (4 F, 3 M; mean age 35 ± 10 yrs), developed severe rheumatic disorders after the first (4) or the third (3) injection of HBV vaccine. Before HBV vaccination, one was a healthy subject and 6 were previously suffering from: eosinophilic fasciitis (1), systemic lupus (1), HLA B27 positive axial ankylosing spondylitis (2), sickle cell disease (1) and idiopathic cutaneous urticaria (1). The underlying disease was in remission induced by treatment (4 cases), including NSAIDs (2), corticosteroids (CS; 1), sulfasalazine (SZ; 2) and hydroxychloroquine (HC; 1) and in 3 cases there was no treatment. Fourteen days (mean) after vaccine injection, they developed rheumatic disorders including: 3 severe symetric polyarthritis fulfilling ARA RA criteria, associated in one case with vasculitis and 2 monoclonal IgM cryoglobulins. Two cases of oligoarthritis (one associated with palatine and laryngeal oedema, ocular sicca syndrome, hypereosinophilia, positive ANA, and C4 defect), 1 case of Sjögren syndrome, 1 severe systemic flare of lupus with arthritis, pleural effusion, vasculitis and a grade IIIa glomerulonephritis.
In all patients these disorders were controlled using prednisone therapy (0.3 to 1 mg/kg/day; 7) combined, according to the underlying rheumatic disease with HC (2), SZ (2), cyclophosphamide (1), azathioprine (1), methotrexate (1) and IV Ig (1). Six patients met a remission after 2 months to one year treatment, but they are still under treatment. In one patient, with eosinophilic fasciitis, a total recovery was observed after 7 years and he has stopped any treatment for 2 years.
Hepatitis B virus vaccination may induce severe reactions requiring the use of a long term treatment (mean period of time of 32.5 ± 24.8 months) in healthy subjects and in patients who suffer from autoimmune diseases and from ankylosing spondylitis or reactive arthritis, even if a complete remission has been already obtained. Abstract: 1186 November 10, 1998 Poster Session D: Miscellaneous Rheumatic Diseases 12:30-2:00 pm, Hall B1/C
Manna R, et al.  Leukoencephalitis after recombinant hepatitis B vaccine. J Hepatol. 1996 Jun;24(6):764-5. No abstract available.PMID: 8835755; UI: 96432703.     
J.F. Maillefert1, J. Sibilia2, E. Toussirot3, E. Vignon4, R. Juvin5, C. Piroth1, D. Wendling3, J.L. Kuntz2, C. Tavernier1, P. Gaudin5 Departments of Rheumatology; 1Dijon; 2Strasbourg; 3Besançon; 4Lyon; 5Grenoble, France
Aim: to obtain an overview of rheumatic disorders occurring after hepatitis B vaccination.
Methods: a questionnaire was sent to rheumatology departments in nine french hospitals. Criteria for entry were rheumatic complaints of one-week duration or more, occurrence during the 2 months following hepatitis B vaccination, no previously diagnosed rheumatic disease, exclusion of bacterial or viral reactive arthritis.
Results: 21 patients (18 women, 3 men; mean age = 30.7 years +/- 12.6 SD) were included. All received recombinant hepatitis B vaccine. The time interval between the vaccination and occurrence of complaints was one week or less for 10 patients, between one week and one month for 8 patients, between one and two months for 3 patients. In 9 patients, the next vaccinal dose was inoculated despite the complaints. The symptomatology worsened in 7 cases, and was not modified in one case (effects unknown for the last patient). The observed disorders were as follows: rheumatoid arthritis for 6 patients, systemic lupus erythematosus for 2, reactive arthritis for 5, polyarthralgia-myalgia-fatigue for 3, suspected or biopsy-proved vasculitis for 3, miscellaneous for 2. Conclusion: hepatitis B vaccination might be followed by various rheumatic conditions, and might trigger the onset of underlying inflammatory and/or auto-immune rheumatic diseases. However, a causal relation between hepatitis B vaccination and the observed rheumatic manifestations cannot be easily established. Further epidemiological works are needed to establish whether hepatitis B vaccination is associated or not with an incidence of rheumatic disorders higher than normal.
Marsaudon E, et al.    [Meningeal reaction after vaccination against hepatitis B]. Presse Med. 1996 Oct 26;25(32):1561-2. French. No abstract available.PMID: 8952667; UI: 97110516.

McIntyre PG. [See Related Articles] Acute hepatitis B infection after vaccination. Lancet. 1995 Jan 28;345(8944):261; discussion 262-3. No abstract available.PMID: 7823744; UI: 95124106.

Macario F, et al.    Nephrotic syndrome after recombinant hepatitis B vaccine. Clin Nephrol. 1995 May;43(5):349. No abstract available.PMID: 7634556; UI: 95361242.   
Mader R, et al.    Systemic vasculitis following influenza vaccination--report of 3 cases and literature review. J Rheumatol. 1993 Aug;20(8):1429-31. Review. PMID: 8230034; UI: 94046875.

Mahassin F, et al.  [Acute myelitis after vaccination against hepatitis B]. Presse Med. 1993 Dec 18;22(40):1997-8. French. PMID: 8127802; UI: 94173824.        
Maillefert JF, et al.     Mental nerve neuropathy as a result of hepatitis B vaccination. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Jun;83(6):663-4. PMID: 9195619; UI: 97339059.
Maillefert JF, et al. Rheumatic disorders developed after hepatitis B vaccination. Rheumatology (Oxford). 1999 Oct;38(10):978-83. PMID: 10534549; UI: 20006401[See Related Articles]

Marsaudon E, et al.  [Meningeal reaction after vaccination against hepatitis B]. Presse Med. 1996 Oct 26;25(32):1561-2. French. No abstract available. PMID: 8952667; UI: 97110516.   

Mathieu E, et al.  Cryoglobulinemia after hepatitis B vaccination. N Engl J Med. 1996 Aug 1;335(5):355. No abstract available.PMID: 8668224; UI: 96283165. 
Masse I, et al.   [Hypersensitivity vasculitis after hepatitis B vaccination]. Presse Med. 1998 Jun 6;27(20):965-6. French. No abstract available.PMID: 9767839; UI: 98440953.

Mamoux V, et al. [Lupus erythematosus disseminatus and vaccination against hepatitis B virus]. Arch Pediatr. 1994 Mar;1(3):307-8. French. No abstract available.PMID: 7994341; UI: 95086590.

Martinez E, et al.  Evans's syndrome triggered by recombinant hepatitis B vaccine. Clin Infect Dis. 1992 Dec;15(6):1051. No abstract available.PMID: 1457642; UI: 93091042.
Meyboom RH, et al. Thrombocytopenia reported in association with hepatitis B and A vaccines. Lancet. 1995 Jun 24;345(8965):1638. No abstract available.PMID: 7632294; UI: 95302878.        

Nagafuchi S, et al.  Eosinophilia after intradermal hepatitis B vaccination. Lancet. 1993 Oct 16;342(8877):998. No abstract available.PMID: 8105253; UI: 94018194.
Neau D, et al. Immune thrombocytopenic purpura after recombinant hepatitis B vaccine: retrospective study of seven cases. Scand J Infect Dis. 1998;30(2):115-8. PMID: 9730294; UI: 98398062.
Nadler JP.  Multiple sclerosis and hepatitis B vaccination. Clin Infect Dis. 1993 Nov;17(5):928-9. No abstract available. PMID: 8286645; UI: 94114816.
Noel I, et al.  Hypersensitivity to thiomersal in hepatitis B vaccine. Lancet. 1991 Sep 14;338(8768):705. No abstract available.PMID: 1679511; UI: 91359780.
Noble JP, et al. [Skin diseases related to hepatitis B vaccine]. Gastroenterol Clin Biol. 1997;21(1):87. French. No abstract available.PMID: 9091400; UI: 97226853.      
No authors listed] [See Related Artices] Report of the working group on the possible relationship between hepatitis B vaccination and the chronic fatigue syndrome. CMAJ. 1993 Aug 1;149(3):314-9. English; French. No abstract available.PMID: 8339178; UI: 93338559.

Niu MT, et al. [See Related Articles] Recombinant hepatitis B vaccination of neonates and infants: emerging safety data from the Vaccine Adverse Event Reporting System. Pediatr Infect Dis J. 1996 Sep;15(9):771-6. PMID: 8878219; UI: 97032323.

Orlando MP, et al.   Sudden hearing loss in childhood consequent to hepatitis B vaccination: a case report. Ann N Y Acad Sci. 1997 Dec 29;830:319-21. No abstract available.PMID: 9616691; UI: 98279663.
Ozdemir S, et al. Nephrotic syndrome associated with recombinant hepatitis B vaccination: a causal relationship or just a mere association? Nephrol Dial Transplant. 1998 Jul;13(7):1888-9. No abstract available.PMID: 9681759; U

Pemberton MN, Sloan P, Thakker NS. Oral lichenoid lesions after hepatitis B vaccination.:Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000 Jun;89(6):717-719 PMID: 10846126

Petousis-Harris H, et al.      Hepatitis B vaccination and diabetes. N Z Med J. 1999 Aug 13;112(1093):303-4. No abstract available.PMID: 10493435; UI: 99421178.

Pennesi M, Torre G, Del Santo M, Sonzogni A.Glomerulonephritis after recombinant hepatitis B vaccine.Pediatr Infect Dis J. 2002 Feb;21(2):172-3.PMID: 11840090 [PubMed - indexed for MEDLINE]

Peyriere H, et al. [Acute pericarditis after vaccination against hepatitis B: a rare effect to be known]. Rev Med Interne. 1997;18(8):675-6. French. No abstract available.PMID: 9365747; UI: 98032451.
Poullin P, et al.    Thrombocytopenic purpura after recombinant hepatitis B vaccine. Lancet. 1994 Nov 5;344(8932):1293. No abstract available.PMID: 7967998; UI: 95057573.
Pope JE, et al.  The development of rheumatoid arthritis after recombinant hepatitis B vaccination. J Rheumatol. 1998 Sep;25(9):1687-93. PMID: 9733447; UI: 98402283.

Reizis Z, et al.     [Allergic vasculitis and bronchial asthma following influenza vaccination]. Harefuah. 1987 Jan 15;112(2):70-1. Hebrew. No abstract available.PMID: 3596383; UI: 87248326.
Rabaud C, et al.  First case of erythermalgia related to hepatitis B vaccination. J Rheumatol. 1999 Jan;26(1):233-4. No abstract available.PMID: 9918272; UI: 99114804.
Ronchi F, et al.    Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine. Arch Dis Child. 1998 Mar;78(3):273-4. PMID: 9613364; UI: 98276312.
Renard JL, et al.   [Acute transverse cervical myelitis following hepatitis B vaccination. Evolution of anti-HBs antibodies]. Presse Med. 1999 Jul 3-10;28(24):1290-2. French. PMID: 10442059; UI: 99370647.       

Saywell CA, et al.     Lichenoid reaction to hepatitis B vaccination. Australas J Dermatol. 1997 Aug;38(3):152-4. Review. PMID: 9293664; UI: 97439212.     
Sebag O, et al.   [Exacerbation of chronic juvenile arthritis induced by hepatitis B vaccination]. Arch Pediatr. 1998 Sep;5(9):1046. French. No abstract available.PMID: 9789643; UI: 99006072.
Senejoux A, et al. [See Related Articles] [Acute myelitis after immunization against hepatitis B with recombinant vaccine]. Gastroenterol Clin Biol. 1996;20(4):401-2. French. No abstract available.PMID: 8758508; UI: 96332745.
Senecal JL, et al. Severe exacerbation of systemic lupus erythematosus after hepatitis B vaccination and importance of pneumococcal vaccination in patients with autosplenectomy: comment on the article by Battafarano et al. Arthritis Rheum. 1999 Jun;42(6):1307-8. No abstract available.PMID: 10366133; UI: 99292255.
Shaw FE Jr, et al. Postmarketing surveillance for neurologic adverse events reported after hepatitis B vaccination. Experience of the first three years. Am J Epidemiol. 1988 Feb;127(2):337-52. Review. PMID: 2962488; UI: 88103514.
During that period, a total of 41 reports were received for one of the following neurologic adverse events: convulsions (five cases), Bell's palsy (10 cases), Guillain-Barre syndrome (nine cases), lumbar radiculopathy (five cases), brachial plexus neuropathy (three cases), optic neuritis (five cases), and transverse myelitis (four cases).
Skowron F, et al.   Persistent nodules at sites of hepatitis B vaccination due to aluminium sensitization. Contact Dermatitis. 1998 Sep;39(3):135-6. No abstract available.PMID: 9771990; UI: 98442988.
Song HK, et al.  Acute Myelitis after hepatitis B vaccination. J Korean Med Sci. 1997 Jun;12(3):249-51. PMID: 9250923; UI: 97394595. 

Sindern E, Schroder JM, Krismann M, Malin JP.   Inflammatory polyradiculoneuropathy with spinal cord involvement and lethal outcome after hepatitis B vaccination.
Neurologische Klinik, BG-Kliniken Bergmannsheil, Ruhr-Universitat, Burkle-de-la-Camp-Platz 1, 44789, Bochum, Germany
J Neurol Sci 2001 May 1;186(1-2):81-5 
We report on a 36-year-old man who developed an inflammatory polyradiculoneuropathy similar to Guillain-Barre syndrome 9 days after hepatitis B vaccination. Extensive immunotherapy including immunoglobulins, steroids, plasmapheresis, cyclophosphamide and methotrexate did not stop the progressive course of the disease and the patient died 4 months later due to multiorgan failure with septic shock symptoms and adult respiratory distress syndrome (ARDS).The neuropathological investigation showed severe axonal loss with mild demyelination of peripheral nerves and mononuclear cell infiltrates, predominantly T-lymphocytes, in nerve roots and spinal ganglia. In addition, there were unusual, perivascular and parenchymal lymphocytic cell infiltrates in the grey matter, especially the anterior horns of the spinal cord. The temporal relationship to hepatitis B vaccination, the strong increase of HBs-antibodies within 3 weeks after vaccination, and the presumptive immune mediated pathology of this disorder suggest a possible etiologic link with hepatitis B vaccine. ------------------------

Solomon A, et al.   Adverse ocular effects following influenza vaccination. Eye. 1999 Jun;13 (Pt 3A):381-2. No abstract available.[MEDLINE record in process]PMID: 10624444; UI: 20089570.
Soubrier M, et al. [Erosive polyarthritis triggered by vaccination against hepatitis B]. Presse Med. 1997 Feb 1;26(2):75. French. No abstract available.PMID: 9082414; UI: 97226581.
Song HK, et al.  Acute Myelitis after hepatitis B vaccination. J Korean Med Sci. 1997 Jun;12(3):249-51. PMID: 9250923; UI: 97394595.    
Snider GB, et al.  A possible systemic reaction to hepatitis B vaccine. JAMA. 1985 Mar 1;253(9):1260-1. No abstract available.PMID: 3155811; UI: 85108365.    
Senejoux A, et al.    [Acute myelitis after immunization against hepatitis B with recombinant vaccine]. Gastroenterol Clin Biol. 1996;20(4):401-2. French. No abstract available.PMID: 8758508; UI: 96332745.    
Soubrier M, et al.   [Erosive polyarthritis triggered by vaccination against hepatitis B]. Presse Med. 1997 Feb 1;26(2):75. French. No abstract available.PMID: 9082414; UI: 97226581.    
 
Stewart O, et al. [See Related Articles] Simultaneous administration of hepatitis B and polio vaccines associated with bilateral optic neuritis. Br J Ophthalmol. 1999 Oct;83(10):1200-1. No abstract available.PMID: 10636652; UI: 20095791.
Toft J, et al.  Subacute thyroiditis after hepatitis B vaccination. Endocr J. 1998 Feb;45(1):135. No abstract available.PMID: 9625459; UI: 98287141.        
Tartaglino LM, et al.   MR imaging in a case of postvaccination myelitis. AJNR Am J Neuroradiol. 1995 Mar;16(3):581-2. PMID: 7793384; UI: 95313683.     
Treves R, et al.  [Erosive nodular rheumatoid arthritis triggered by hepatitis B vaccination]. Presse Med. 1997 Apr 26;26(14):670. French. No abstract available.PMID: 9180887; UI: 97324782.
Trevisani F, et al. Transverse myelitis following hepatitis B vaccination. J Hepatol. 1993 Sep;19(2):317-8. No abstract available.PMID: 8301068; UI: 94132548.        
Tourbah A, et al.  Encephalitis after hepatitis B vaccination: recurrent disseminated encephalitis or MS? Neurology. 1999 Jul 22;53(2):396-401. PMID: 10430433; UI: 99357502.   
Tuohy PG.  Guillain-Barre syndrome following immunisation with synthetic hepatitis B vaccine. N Z Med J. 1989 Mar 8;102(863):114-5. No abstract available.PMID: 2522608; UI: 89182804.        
Tudela P, et al.   Systemic lupus erythematosus and vaccination against hepatitis B. Nephron. 1992;62(2):236. No abstract available.PMID: 1436323; UI: 93063627.    
Tosti ME, et al. Multiple sclerosis and vaccination against hepatitis B: analysis of risk benefit profile.  Ital J Gastroenterol Hepatol. 1999 Jun-Jul;31(5):388-91.   PMID: 10470598; UI: 99399619.
Vial T, et al.    [Vasculitis after anti-influenza vaccination. Report of 5 cases]. Therapie. 1990 Nov-Dec;45(6):509-12. French.
PMID: 2080490; UI: 91180873.   

Vanoli M, et al.  A case of Churg-Strauss vasculitis after hepatitis B vaccination. Ann Rheum Dis. 1998 Apr;57(4):256-7. No abstract available.PMID: 9709187; UI: 98374849.
Vautier G, et al.   Acute sero-positive rheumatoid arthritis occurring after hepatitis vaccination. Br J Rheumatol. 1994 Oct;33(10):991. No abstract available.PMID: 7921766; UI: 95006007.  

Voigt U, Baum U, Behrendt W, Hegemann S, Terborg C, Strobel J.  [Neuritis of the optic nerve after vaccinations against hepatitis A, hepatitis B and yellow fever] Klin Monatsbl Augenheilkd. 2001 Oct;218(10):688-90. German.PMID: 11706386 [PubMed - indexed for MEDLINE]

Waugh MA. [See Related Articles] Acute hepatitis B infection after vaccination. Lancet. 1995 Jan 28;345(8944):262; discussion 262-3. No abstract available.PMID: 7823746; UI: 95124109.

Waisbren BA Sr. [See Related Articles] Universal hepatitis B vaccinations. Wis Med J. 1996 Mar;95(3):148. No abstract available.PMID: 8775278; UI: 96371443.

Vaccine safety

NA, "The Risk of AIDS after Hepatitis Vaccination," JAMA, 1985 May 24-31; 253(20):2960-2961.

Francis, DP, et al, "The Safety of the Hepatitis B Vaccine. Inactivation of the AIDS virus During Routine Manufacture", JAMA, 1986 Aug 15; 256(7): 869-872.

Kato, S et al, "Hepatitis B Vaccination and AIDS," JAMA, 1985 Jul 5; 254(1):53.

Macek, C, "AIDS Transmission: What about the Hepatitis B Vaccine?", JAMA, 1983 Feb 11; 249(6):685-686.

Papaevangelou, G et al, "Risk of AIDS in Recipients of Hepatitis B Vaccine", NEJM, 1985 Feb 7; 312(6):376-377.

Scheier, R, Hepatitis vaccine: the Danger of AIDS Transmission, Z Hautkr, 1984 Apr 15; 59(8):502-506.

Schwartz, AM, et al, "Hepatitis Vaccine and the Acquired Immunodeficiency Syndrome", 1983, JAMA, Oct: 99(4):567-568.

Sacks, H S, et al, "Should the Risk of Acquired Immunodeficiency Syndrome deter Hepatitis B Vaccination?" A Decision Analysis." JAMA, 1984 Dec 28; 252(24): 3375-3377.

Taubman, L B, et al, "The Question of Possible Relationship Between Hepatitis B Vaccine and AIDS", AM J Med, 1984 Apr; 76(4): A 59.

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