Postvaccinal Encephalitis

Encephalitis

Table of case-fatality rate of post-vaccinial encephalitis

[2009 Oct] Valley Mom Blames Vaccines For Illness  Phoenix resident Melissa Ellingson said tetanus and flu shots she received this summer nearly cost her her life. “I couldn't talk. I couldn't walk. I couldn't feel my whole body. It was like I had an epidural of something,” Ellingson said. She developed encephalitis, or inflammation of the brain, about a month after the two vaccines.

[March 2007] Early fears about MMR in secret papers

Anna [MMR--paralysis, post vaccination encephalopathy]

Encephalitis: An acute inflammatory disease of the brain due to direct viral invasion or to hypersensitivity initiated by a virus or other foreign protein......Secondary encephalitis, usually a complication of viral infection, is considered to have an immunologic mechanism. Examples are encephalitides secondary to measles, chickenpox, rubella, smallpox vaccination, vaccinia, and many other less well defined viral infections. (Merck manual) http://www.merck.com/pubs/mmanual/section14/chapter176/176c.htm

Vaccine-associated neurotropic disease,  (previously described as post-vaccinal encephalitis)

Many of the mothers noticed that their children had a high-pitched cry soon after their vaccination or vaccinations. This is called the encephalitic cry, meaning that it is caused by an inflamed, swollen brain. It also explains the difficulty many mothers have in waking their children, the vomiting, passing out and irritability following vaccinations. These are all signs of an inflamed brain. The reason that pediatricians are telling these mothers that their children's reactions to these vaccines are normal is based on at least two factors. One, most pediatricians, in my experience, know absolutely nothing about a child's brain. When I was practicing, if anything happened to a pediatrician's patient that in any way indicated something was wrong with the child's brain, the doctor was on the phone with me in an instant. Most admitted they knew nothing about the brain. The second reason is that they are trying to avoid a lawsuit. If they can convince the mother that everything is well, they may avoid a trip to the courtroom. Most physicians are gunshy about lawsuits. It can also hurt their reputation. Vaccine Safety Manual  by Neil Z. Miller. Preface

[March 2008] [SO THERE ARE MORE HANNAH POLINGS WE JUST DON'T KNOW ABOUT? GOTCHA, JUDGE.--Dan Olmsted We were also compensated by the Federal Government in 2002.  Our child suffered the same diagnosis after her routine immunizations.  Encephalopathy with autistic like symptoms.  I am not sure why people think this is the first case?  Maybe they are just the first to go so public.  I wonder how many other families have been compensated for the exact same symptoms?  When we settled with the government I did not get the impression that we were that unique; quite the opposite as I spoke to the Special Master (the judge for the compensation program).  - Misty Hiatt

Somewhat 35 years ago, when I worked in Gamaleya Institute of Epidemiology and Microbiology, a leading Russian center for vaccines development and immunology research, a tragedy happened: our measles vaccine caused an epidemics of encephalitis among vaccinated. Our senior immunologist and virologist, prof. Svet-Moldavsky, was sent to investigate. It turned out that at producing facility they slightly modified protocol, using overgrown rats instead of very young, as was required. Live virus vaccines are made nowadays essentially as in days of Pasteur, by multiple passage on animals brains. So these vaccines can induce antibody production not only to virus antigenes, but to components of brain tissue as well. While antigene composition of human and animals tissues is different, some overlapping exists, so autoimmune response against brain tissue of vaccinated children is possible. This happened in this case. The story never leaked into press, of course, due to Soviet era secrecy, but everybody in Institute knew it.
     Measles lethality drastically plummeted in last few decades, from several procents to one case in thousand infected. Most of it was due to concurrent bacterial infection pneumonia, which now effectively treated by antibiotics; these 1/1000 deaths are also caused not by virus itself, but autoimmune reaction on this virus targeting brain tissue. But there are sound reasons to fear that attenuated vaccine virus can induce analogic reactions. Many parents reported onset of autism symptoms immediately (several hours after) vaccination. Too early for viremia, but timing is exact for autoimmune reaction. The Wakefield witch-hunt--Melanie Phillips

"Today, there are about 150 vaccines being worked on, and within the next decade, we could have a flu vaccine for the left nostril and one for one right nostril. Mankind will be used as a pin cushion. For every vaccination, minimal encephalopathy destroys brain cells. As a result, in Germany, there are 1.2 million children who have contracted hyperkinetic syndrome who are then treated with Psychopharmeca (a drug similar to Ritalin) used to calm them down... We have hundreds of thousands of so-called minimal cerebral dysfunction cases and millions of neurodermatitis patients. In Germany, there are millions of people with allergies. We don’t just produce minimal encephalopathies in the brain, but we also produce modifications of the genetic code."--Dr Buchwald MD[Media Sept 2002] Bosnia halts using Unicef-donated DTP vaccines after baby contracts encephalitis

"What could be the cause of so much encephalitis in the US population? The only possible cause is the childhood vaccination program. The pertussis and measles vaccines are particularly dangerous, but all the vaccines have made a certain contribution."--Harris Coulter

"The United States Public Health Bureau is extremely reticent about reporting diseases caused by vaccination but the report from 1922 to 1931 admitted that there had been 85 cases of post-vaccinal encephalitis, which DeKruif states "is the twin of infantile paralysis.""--Eleanor McBean

"He fell sick with a post-vaccination encephalitis, and ever since, I have a completely destroyed human being at home."--Dr G Buchwald MD

"His mother took him for a DT booster, which changed his life. He got encephalitis from the vaccine. Extensive hospital work proved that there was no other possible cause, and in the work-up for ACC, Professor David Holdaway, New Zealand's strongest proponent for vaccination, wrote the report for ACC which stated that there was no doubt that this was a case of vaccine damage."--Hilary Butler http://www.netlink.co.nz/~ias/diphtheria.htm

Disintegrative psychosis is recognised as a sequel to measels encephalitis.Viral encephalitis can give rise to autistic disorders, particularly when it occurs early in life. *Wing L, The autistic Spectrum London Constable, 1996 pg 68-71

Infantile encephalitis - inflammation of the brain in children following infections,injury,etc.,and causing the cerebral palsies of children.    ENCYCLOPEDIA  AND DICTIONARY OF MEDICINE AND NURSING;  MILLER AND KEANE.

National Vaccine Injury Compensation Program Vaccine Injury Table http://www.hrsa.dhhs.gov/bhpr/vicp/table.htm#

Measles-Mumps-Rubella (MMR) Vaccine as a Potential Cause of Encephalitis (Brain Inflammation) in Children-----Harold E. Buttram, MD

Antony SJ, et al.    Postvaccinial (influenza) disseminated encephalopathy (Brown-Sequard syndrome). J Natl Med Assoc. 1995 Sep;87(9):705-8. Review. PMID: 9583968; UI: 98242646.

Askanas A;   [Postvaccinal encephalitis and enterovirus infection] (Pediatr Pol, 1966 Feb)

Buchner H, et al.   [Polyneuritis cranialis? Brain stem encephalitis and myelitis following preventive influenza vaccination]. Nervenarzt. 1988 Nov;59(11):679-82. German. No abstract available.PMID: 3211251; UI: 89097428   

Buchwald G;   [Postvaccinal encephalitis and encephalopathy] (Med Welt, 1971 Oct 22) Buchwald G, et al.   

Harold E. Buttram, MD, Townsend Letters, December 1997"Measles-Mumps-Rubella (MMR) Vaccine as a Potential Cause of Encephalitis (Brain Inflammation) in Children," .

Bitnun A, et al.   Measles inclusion-body encephalitis caused by the vaccine strain of measles virus. Clin Infect Dis. 1999 Oct;29(4):855-61. PMID: 10589903; UI: 20055848.
Barbor PR, et al.  Encephalitis after measles vaccination. Lancet. 1969 Jul 5;2(7610):55-6. No abstract available.PMID: 4182814; UI: 69218681.       
Braginskaia VP, et al. [Postvaccinal encephalitis in a child aged 3 years and 4 months]. Vopr Okhr Materin Det. 1968 Apr;13(4):75-7. Russian. No abstract available.PMID: 4387468; UI: 69083500.
Begg NT, et al.    Mumps, measles, and rubella vaccination and encephalitis. BMJ. 1989 Oct 14;299(6705):978. No abstract available.PMID: 2553173; UI: 90029090.
Baylet RJ, et al.  [Post-vaccinal encephalitis: a virologic study]. Bull Soc Med Afr Noire Lang Fr. 1966;11(1):83-92. French. No abstract available.PMID: 4380154; UI: 66158420.         

Campbell AG.     Mumps, measles, and rubella vaccination and encephalitis. BMJ. 1989 Oct 7;299(6704):916. No abstract available.PMID: 2510888; UI: 90057796.

Cho CT, et al. Panencephalitis following measles vaccination. JAMA. 1973 May 28;224(9):1299. No abstract available.PMID: 4739905; UI: 73173566.[See Related Articles]

Collomb H, et al.   [Postvaccinal encephalitis (yellow fever vaccination); neuro-radiological study]. Bull Soc Med Afr Noire Lang Fr. 1966;11(3):587-90. French. No abstract available.PMID: 4382457; UI: 67213214.  

Collomb H, et al.   [Neuro-psychic syndromes during postvaccinal encephalitis]. Bull Soc Med Afr Noire Lang Fr. 1966;11(3):575-86. French. No abstract available.PMID: 4382456; UI: 67213213        

Cavanagh, NPC (1981); Brett, EM; Marshall, WC; Wilson, J; The Possible Adjuvant Role of Bordetella Pertussis and Pertussis Vaccine in Causing Severe Encephalopathic Illness: a Presentation of Three Case Histories; Neuropediatrics 12: 374-381 (1981)
The clinical and some laboratory details of three children who had severe neurological sequelae after either infection with Bordetella pertussis or immunisation with diphtheria, tetanus and pertussis vaccine and oral polio vaccine are reported. Each of these patients had had a recent or concurrent viral illness. The severity of their encephalopathic illness may have been due to an adjuvant role of B. pertussis or a component of the vaccines they received.

Crowley S, et al.  Mumps, measles, and rubella vaccination and encephalitis. BMJ. 1989 Sep 9;299(6700):660. No abstract available.PMID: 2572289; UI: 90028978.        
 

Cherry, J.D (1988)., Brunell, P.A., Golden, G.S., Karzon, D.T., (1988), Report of the task force on pertussis and pertussis immunization, Pediatrics 81:6 Part 11 (June 1988) Supplement pp 936-984.
Extract: For more than 25 years, it has been known that pertussis vaccine is a reliable adjuvant for the production of experimental allergic encephalitis.7499"8 This experimental allergic encephalomyelitis is mediated by sensitized lymphocytes rather than serum antibody mechanisms.52 Pertussis vaccine has also been used as an adjuvant in the following experimental autoimmune diseases: thyroiditis, myocarditis, glomerulonephritis, uveoretinitis, and hemolytic anemia.49"9 Except for the adjuvant effect upon antibody responses to specific vaccines, there is no evidence that any of the experimental adjuvant activities of pertussis vaccine, and specifically LPF, occur in vaccinated children.

Dzagurov SG, et al.  [Results of a study of the pathogenesis of postvaccinal encephalitis]. Vopr Virusol. 1981 Jul-Aug;(4):398-404. Russian. PMID: 6117985; UI: 82063785.
Dietzsch HJ.   [Encephalitis following 1st smallpox vaccination despite pretreatment with vaccine antigens]. Kinderarztl Prax. 1966 Sep;34(9):425-8. German. No abstract available.PMID: 4162053; UI: 67015784.  
Ehrengut W.   Smallpox vaccination following childhood postvaccinal encephalitis. JAMA. 1973 Aug 27;225(9):1123. No abstract available.PMID: 4146661; UI: 73230617.
Ehrengut W. [Diabetes mellitus from post-vaccinal encephalitis]? Dtsch Med Wochenschr. 1970 May 15;95(20):1135. German. No abstract available. PMID: 4392770; UI: 70188407.

Finley, K H, "Pathogenesis of Encephalitis Occurring With Vaccination, Variola and Measles, Arch Neur and Psychologist, 1938; 39:1047-1054.

Froissart M, et al.    [Acute meningoencephalitis immediately after an influenza vaccination]. Lille Med. 1978 Oct;23(8):548-51. French. No abstract available.PMID: 723420; UI: 79072015   

Fejerman N;   [Post-vaccinal encephalitis] (Arch Argent Pediatr, 1964 Oct-Dec)
Gross WL, et al.  Meningoencephalitis syndrome following influenza vaccination. J Neurol. 1978 Feb 14;217(3):219-22. PMID: 75958; UI: 78132024.

Gamboa ET, Cowen D, Eggers A, Cogan P, Ganti R, Brust JC.Delayed onset of post-rabies vaccination encephalitis.Ann Neurol. 1983 Jun;13(6):676-8.PMID: 6136253 [PubMed - indexed for MEDLINE]

Gurvich EB, et al. Isolation of vaccinia virus from children with postvaccinal encephalitis at late intervals after vaccination. Acta Virol. 1975 Jan;19(1):92. No abstract available.PMID: 235206; UI: 75125625.[See Related Articles]

Gurvich EB, et al.  Vaccinia virus in postvaccinal encephalitis. Acta Virol. 1983 Mar;27(2):154-9. PMID: 6135334; UI: 83252750.   
Horn W. [Encephalitis following smallpox vaccination]. Z Arztl Fortbild (Jena). 1965 Nov 15;59(22):1204-6. German. No abstract available. PMID: 4161632; UI: 66172634.
Jagdis F, et al.  Encephalitis after administration of live measles vaccine. Can Med Assoc J. 1975 Apr 19;112(8):972-5. PMID: 236821; UI: 75166215.
Jorch G, et al.  [Coincidence of virus encephalitis and measles-mumps vaccination]. Monatsschr Kinderheilkd. 1984 May;132(5):299-300. German. PMID: 6146928; UI: 84270405.
Jennings AD, et al.   Analysis of a yellow fever virus isolated from a fatal case of vaccine-associated human encephalitis. J Infect Dis. 1994 Mar;169(3):512-8. PMID: 7908925; UI: 94209744.       

Jorch G, et al.  [Coincidence of virus encephalitis and measles-mumps vaccination]. Monatsschr Kinderheilkd. 1984 May;132(5):299-300. German. PMID: 6146928; UI: 84270405      

Kim TM, et al.  Delayed acute measles inclusion body encephalitis in a 9-year-old girl: ultrastructural, immunohistochemical, and in situ hybridization studies. Mod Pathol. 1992 May;5(3):348-52. PMID: 1353879; UI: 92357667.
Klingmuller G.  [Smallpox vaccinations and post-vaccinal encephalitis]. Med Welt. 1965 Jul 17;29:1653-4. German. No abstract available.PMID: 4378496; UI: 66004721.       
Sen Gupta PN, et al. Post-vaccinal encephalitis. Report of a case. Indian J Pediatr. 1975 Dec;42(335):356-7. No abstract available. PMID: 6390; UI: 76212084.
Klingmuller G. [Smallpox vaccinations and post-vaccinal encephalitis]. Med Welt. 1965 Jul 17;29:1653-4. German. No abstract available.PMID: 4378496; UI: 66004721.
Koskiniemi M, et al.     Effect of measles, mumps, rubella vaccination on pattern of encephalitis in children. Lancet. 1989 Jan 7;1(8628):31-4. PMID: 2563011; UI: 89096098.

Kreiner R, et al.    [Encephalitis after rabies vaccination]. Psychiatr Neurol Med Psychol (Leipz). 1971 Sep;23(9):532-6. German. No abstract available.PMID: 4403287; UI: 72258327.    
Louis JJ, et al.   [A case of encephalitis after anti-yellow fever vaccination with the 17 D strain]. Pediatrie. 1981 Oct-Nov;36(7):547-50. French. No abstract available.PMID: 6119675; UI: 82105325     

Labauge R, et al. Postvaccinal encephalitis in adult. A case with anatomo-clinical report. Rev Neurol (Paris). 1979;135(11):803-13. French. PMID: 45321; UI: 81125716.The case reported concerns a man of 27 years who presented 10 days after a polyvaccination (7 vaccines in 2 months) altered consciousness, epileptic fits, right hemiplegia, vegetative dysfunctions and meningeal status. Evolutionary clinical course led to death in 21 days.

Meerbach W, et al.   [Encephalitis following smallpox revaccination]. Schweiz Med Wochenschr. 1971 Sep 11;101(36):1311-5. German. No abstract available.PMID: 4401022; UI: 72132896    
Mar ID, et al.    [Encephalitis following anti-yellow fever vaccination]. Ann Pediatr (Paris). 1967 Mar 2;14(3):181-91. French. No abstract available.PMID: 4387264; UI: 69064560.

Naumova, R P, et al, "Encephalitis Developing After Vaccination without a Local Skin Reaction", Vrach Delo, Jul 1979, (7):114-115.
Nalin DR.      Mumps, measles, and rubella vaccination and encephalitis. BMJ. 1989 Nov 11;299(6709):1219. No abstract available.PMID: 2574604; UI: 90089702  
No authors listed]  Fatal viral encephalitis following 17D yellow fever vaccine inoculation. Report of a case in a 3-year-old child. JAMA. 1966 Nov 7;198(6):671-2. No abstract available.PMID: 4380787; UI: 67043249.       

Osvath P, et al. IgE levels of infants with complications after pertussis vaccination. Allergol Immunopathol (Madr). 1979 Mar-Apr;7(2):111-4. PMID: 463714; UI: 79228768.
IgE levels of 31 infants who had severe complications after whooping cough vaccination, were determined by RIST. The patients had convulsions, encephalitis or anaphylactic shock symptoms. All but two had elevated IgE levels for their age. It is suggested that, in certain genetically predisposed human beings, pertussis antigen can also induce IgE synthesis, as has already been established in rodents. PMID: 463714, UI: 79228768
Palmar I, et al.     [Encephalopathy after vaccination against smallpox with permanent sequel--diabetes insipidus]. Vojnosanit Pregl. 1972 May;29(5):242-4. Serbo-Croatian (Roman). No abstract available.PMID: 4402923; UI: 72233718.      

Pollock TM, et al Safety of pertussis vaccine. Lancet. 1983 Oct 1;2(8353):795-6. No abstract available. PMID: 6137630; UI: 84012855.
Reported 8 children with anaphylaxis or collapse within 24 hours of DPT vaccination, for a rate of 6 cases per 100,000 children vaccinated

Ravkina LI, et al.   [Postvaccinal encephalopathy]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1973;73(2):191-4. Russian. No abstract available.PMID: 4147549; UI: 74006550.       

Rafalowska J;   [Case of encephalitis necroticans acuta in the course of postvaccinal reaction] (Neuropatol Pol, 1965 Oct-Dec)
Romanov VA, Bereshkova RV.   Zh Mikrobiol Epidemiol Immunobiol 1975 Jun;(6):66-72 [Pathomorphological and immunofluorescent studies of smallpox vaccine neurotropism]. [Article in Russian]  Experiments were conducted on guinea pigs sensitized with the AK C-vaccine components. In intracardiac injection with smallpox vaccine there was shown a possibility of development of marked hemodynamic disturbances, of the inflammatory-dystrophic processes of irreversibel character, with a subsequent neuronophagia and demyelinization. Injection of smallpox vaccine into the circulation of intact guinea pigs was accompanied by development in the nervous system of insignificant circulatory disturbances and of the inflammatory dystrophic phenomena of reversible character. A method of immunofluorescence was used and the antigen of the vaccine virus was revealed in the neurons of the brain and the spinal cord of the sensitized and intact animals. Marked hemodynamic and insignificant inflammatory-dystrophic processes were revealed in the nervous system of a child which died of the post-vaccinal encephalitis; an antigen of the smallpox virus was found by the immunofluorescent method in the nerve cells and the vessels in various portions of the nervous system. PMID: 239507, UI: 75221294

Salwa S. [Encephalitis following smallpox vaccination]. Wiad Lek. 1973 Feb 1;26(3):215-9. Review. Polish. No abstract available.PMID: 4144404; UI: 73149830.

Saito H, et al.     Acute disseminated encephalomyelitis after influenza vaccination. Arch Neurol. 1980 Sep;37(9):564-6. PMID: 7417057; UI: 81020711.     
Schwebke D, et al.    [Clinical and EEG course observations in postvaccinal encephalitis with fatal outcome]. Kinderarztl Prax. 1974 Jul;42(7):307-12. German. No abstract available.PMID: 4155459; UI: 75080434.    

Schoub BD, et al.     Encephalitis in a 13-year-old boy following 17D yellow fever vaccine. J Infect. 1990 Jul;21(1):105-6. PMID: 2384674; UI: 90347226. 
Sen Gupta PN, et al.  Post-vaccinal encephalitis. Report of a case. Indian J Pediatr. 1975 Dec;42(335):356-7. No abstract available.PMID: 6390; UI: 76212084.   
Trajkov N, et al.  [Encephalitis after smallpox vaccination]. God Zb Med Fak Skopje. 1971;17:469-75. Serbo-Croatian (Cyrillic). No abstract available.PMID: 4156973; UI: 76003870.     
Tjakradinata D, et al.  Post-vaccinal encephalitis. Paediatr Indones. 1977 Nov-Dec;17(11-12):385-93. No abstract available.PMID: 24200; UI: 78115076.      
Tourbah A, Gout O, Liblau R, Lyon-Caen O, Bougniot C, Iba-Zizen MT, Cabanis EA Neurology 1999 Jul 22;53(2):396-40. Encephalitis after hepatitis B vaccination: recurrent disseminated encephalitis or MS? Federation de Neurologie, Hopital de la Salpetriere and Faculte de Medecine Pitie-Salpetriere (Paris VI) France.
OBJECTIVE: To describe clinical and MRI features of patients with a disease suggestive of CNS inflammation after hepatitis B vaccination. METHODS: Eight patients with confirmed CNS inflammation occurring less than 10 weeks after hepatitis B vaccination are described. They received follow-up clinically and on MRI for a mean period of 18 months. RESULTS: Clinical and MRI findings were compatible with acute disseminated encephalomyelitis. However, clinical follow-up, repeated MRI, or both showed the persistence of inflammatory activity, which makes this encephalitis more suggestive of MS than of acute disseminated encephalomyelitis. CONCLUSION: The persistent inflammatory activity observed clinically and on MRI in these patients is comparable with that usually observed in MS. Epidemiologic studies are currently testing the hypothesis of a triggering role of hepatitis B vaccination in CNS demyelination. PMID: 10430433, UI: 99357502

Vilesova IS, et al. [Changes in the properties of the vaccinia virus isolated in postvaccinal encephalitis]. Vopr Virusol. 1985 Jul-Aug;30(4):477-82. Russian. PMID: 2865855; UI: 86046186.       
Vich V. [Contribution on the problem of allergic cerebral edema, following smallpox vaccination, that imitates post-vaccinal encephalitis].  Z Arztl Fortbild (Jena). 1968 Nov 1;62(21):1183-5. German. No abstract available. PMID: 4389294; UI: 69219963. 

Watson JG.   A child of 3 years who developed an encephalitic reaction to MMR (mumps, measles, rubella) immunisation at age 15 months. Int J Pediatr Otorhinolaryngol. 1990 Jun;19(2):189-90. No abstract available.PMID: 2373602; UI:
White F.    Measles vaccine associated encephalitis in Canada. Lancet. 1983 Sep 17;2(8351):683-4. No abstract available.PMID: 6136823; UI: 83296456.  
Wiersbitzky S, et al.    [Encephalitis, meningitis serosa and parotitis after MMR preventive vaccination? The Pediatric Vaccination Counseling Unit]. Kinderarztl Prax. 1992 Oct;60(7):203-5. German. No abstract available.PMID: 1359186; UI: 93060684.
Wiersbitzky S, et al.    [Encephalitis after simultaneous DPT and oral trivalent poliomyelitis (Sabin vaccine) and HiB preventive vaccination]? Kinderarztl Prax. 1993 Jun;61(4-5):172-3. German. No abstract available.PMID: 8103131; UI: 93368099.
Wiersbitzky S, et al.    ["Vaccination encephalopathy after measles vaccination simulating recurrent cardiovascular dysregulation?" The pediatric vaccination counseling unit]. Kinderarztl Prax. 1991 Jun;59(6):187-8. German. No abstract available.PMID: 1681130; UI: 92016158.
Wiersbitzky S, et al.     [Cerebral seizures and/or encephalitis after MMR, oral polio, HiB or DPT vaccination]? Kinderarztl Prax. 1993 Aug;61(6):232-4. German. No abstract available.PMID: 8105136; UI: 94017415.
 

National childhood encephalopathy study in 1976-9

http://members.aol.com/danielsown/encephalitis/emily.htm

 

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