Arthritis and vaccines
Diseases  Vaccines & disease

Juvenile rheumatoid arthritis afflicts 300,000 American children. Twenty-five years ago this disease was so rare that public health officials did not keep any statistics on it. There has been a 4-fold increase in asthma, and bowel disorders in children are much more common now than they were 50 years ago. A User-Friendly Vaccination Schedule by Donald W. Miller, Jr., MD

[Squalene] …Our demonstration that an autoadjuvant can trigger chronic, immune-mediated joint-specific inflammation may give clues to the pathogenesis of rheumatoid arthritis, and it raises new questions concerning the role of endogenous molecules with adjuvant properties in chronic inflammatory diseases. The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats

"Jenny Marra, a New Jersey hospice nurse positive for HLA-DR4, said she had been living with "severe joint and muscle pain since vaccination in 1999. SmithKline did not include a warning about the potential risk for this information in the product labeling or inform the health care providers of this concern. Had I known this I personally would not have taken the vaccine." Physicians aware of the political controversy, she added, are turning the LYMErix vaccine victims away "with statements like, 'I don't want to get involved.'" --The Bitter Feud over LYMErix Big Pharma Takes on the Wrong Little Osp

David A Geier, Mark R Geier MD PhD. Chronic adverse reactions associated with hepatitis B vaccination The Annals of Pharmacotherapy 2002: Vol. 36, No. 12, pp. 1970–1971.
In conclusion, our study demonstrates that adult HBV is statistically associated not only with acute neuropathy, neuritis, myelitis, vasculitis, thrombocytopenia, gastrointestinal disease, multiple sclerosis, and arthritis, but some of these patients go on to develop chronic adverse reactions that persist for at least 1 year following HBV. These types of chronic adverse reactions following adult HBV should be discussed with patients contemplating being immunized with HBV and should be included in the differential diagnosis of those who develop them following adult HBV.

Science has proven that the following conditions may all be caused by the aluminum-hydroxide in vaccines: Chronic fatigue, Multiple sclerosis , Lou Gehrig’s disease, Demyelinating central nervous system disorders, Plymyalgia rheumatica and rheumatoid arthritis, Motor delay, Hypotonia or diminished muscle tone, Failure to thrive, Apoptic neurons, which are self-destructing neurons in the lumbar spinal cord, Neuron loss in the lumbar spinal cord. I’ve known for over four years now that aluminum was bad for the body, but as usual, I just didn’t know how bad it is. However, there is plenty of scientific evidence, hidden in plain sight, proving the pervasiveness and toxic nature of aluminum in our world today. Aluminum-hydroxide in vaccines causes serious health problems By Tenna Merchant

Citations

[Media UK, Jan 9, 2003, MMR arthritis] The MMR jab turned our healthy girl into a cripple Rebekah Boyd

VACCINATION AND ARTHRITIS REVISITED Reported by Anabel Aron-Maor

My experience-arthritis and tetanus vaccine

Package insert (Hep B)

LETTERS: LYMErix vaccine

LYME VACCINE LINKED TO AUTOIMMUNE ARTHRITIS

Lyme disease vaccine & arthtitis

Case studies of hepatitis B vaccine damage

Children with adverse effects from Hep B vaccine

Package insert hepatitis B vaccine

[Media Spring 1994 Tetanus vaccine--arthritis] Letter to Mothering Magazine

Hepatitis B Immunization Linked to Autoimmune Rheumatic Diseases 

Testimony of Betty D. Fluck---Effectiveness of Hepatitis B Vaccine May 18, 1999  

Hep B vaccine info (Dr Bonnie Dunbar)

Hepatitis B vaccines - musculoskeletal reactions----Australian adverse drug reactions bulletin

[Media] TEENAGER'S ARTHRITIS AGONY (Meningitis C vaccine)

National Vaccine Injury Compensation Program Vaccine Injury Table http://www.hrsa.dhhs.gov/bhpr/vicp/table.htm#

Holmdahl R, Lorentzen JC, Lu S, Olofsson P, Wester L, Holmberg J, Pettersson U.  Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis. Immunol Rev. 2001 Dec;184:184-202. PMID: 12086312 [PubMed - in process]
Rat models are useful for studies of the pathogenesis of rheumatoid arthritis (RA) since rats are extraordinarily sensitive to induction of arthritis with adjuvants. Injection of not only the classical complete Freund's adjuvant but also mineral oil without mycobacteria and pure adjuvants such as pristane and squalene, induce severe arthritis in many rat strains. Models like pristane-induced arthritis in rats are optimal models for RA since they fulfill the RA criteria including a chronic relapsing disease course. Arthritogenic adjuvants like pristane, avridine, squalene and mineral oil are not immunogenic since they do not contain major histocompatibility complex (MHC) binding peptides. Nevertheless, the diseases are MHC-associated and dependent on the activation of alphabetaTCR (T-cell receptor)-expressing T cells. However, it has not been possible to link the immune response to joint antigens or other endogenous components although immunization with various cartilage proteins induce arthritis but with different pathogeneses. To unravel the mechanisms behind adjuvant-induced arthritis, a disease-oriented genetic approach is optimal. Several loci that control onset of arthritis, severity and chronicity of the disease have been identified in genetic crosses and most of these have been confirmed in congenic strains. In addition, many of these loci are found in other autoimmune models in the rat as well as associated with arthritis in mice and humans.

(American Journal of Pathology. 2000;156:2057-2065.) © 2000 American Society for Investigative Pathology The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats, Barbro C. Carlson*, Åsa M. Jansson*, Anders Larsson , Anders Bucht * and Johnny C. Lorentzen* , From the Department of Medicine,*Unit of Rheumatology, Karolinska Institutet, Stockholm; the Department of Medical Sciences, University Hospital, Uppsala; and the Department of Biomedicine, Division of NBC Defense, Defense Research Establishment, Umeå, Sweden

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