"In the unvaccinated group, there were no significant associations
between pertussis infection and atopic disorders.

In the vaccinated
group, all associations between pertussis infection and atopic
disorders were positive, the associations with asthma [odds ratio
(OR) = 2.24, 95% confidence interval (CI(95%)): 1.36-3.70], hay fever
(OR = 2.35, CI(95%): 1.46-3.77) and food allergy (OR = 2.68, CI(95%):
1.48-4.85) being significant. There was a positive association
between pertussis infection and atopic disorders in the pertussis
vaccinated group only. From the present study, it cannot be concluded
whether this association is causal or due to reverse causation."


Pediatr Allergy Immunol. 2008 Feb;19(1):46-52. Epub 2007 Dec
11.Related Articles, Links
Reported pertussis infection and risk of atopy in 8- to 12-yr-old
vaccinated and non-vaccinated children.

http://www.ncbi.nlm.nih.gov/pubmed/18086216?dopt=Abstract

Bernsen RM, Nagelkerke NJ, Thijs C, van der Wouden JC.

Department of General Practice, Erasmus MC - University Medical
Center Rotterdam, Rotterdam, The Netherlands. roos.bernsen@uaeu.ac.ae

Pertussis infection has been suspected to be a potential causal
factor in the development of atopic disease because of the effect of
pertussis immunization on specific IgE antibodies. Although several
studies found a positive association between pertussis infection and
atopic disorders, this relationship has not yet been studied in a
population stratified by vaccination status. To assess the
association between pertussis infection and atopic disorders in
pertussis-unvaccinated children and in pertussis-vaccinated children.
Using data from a previously conducted study on the relationship
between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis
vaccination in the first year of life and atopic disorders, the study
population of 1872 8-12 yr old was divided into children pertussis-
unvaccinated and children pertussis-vaccinated in the first year of
life. Within each group, the association between pertussis infection
and atopic disorders (both as reported by the parents) was assessed.
In the unvaccinated group, there were no significant associations
between pertussis infection and atopic disorders. In the vaccinated
group, all associations between pertussis infection and atopic
disorders were positive, the associations with asthma [odds ratio
(OR) = 2.24, 95% confidence interval (CI(95%)): 1.36-3.70], hay fever
(OR = 2.35, CI(95%): 1.46-3.77) and food allergy (OR = 2.68, CI(95%):
1.48-4.85) being significant. There was a positive association
between pertussis infection and atopic disorders in the pertussis
vaccinated group only. From the present study, it cannot be concluded
whether this association is causal or due to reverse causation.

PMID: 18086216 [PubMed - in process]