Peer-reviewed studies documenting cases of shingles following varicella vaccination.
2009 Nov
Comments from Gary Goldman, researcher on the below article:
The author is incorrect in many factual points in the above narrative. Let's
restrict comments to this particular sentence, "And getting chickenpox as
a child puts a person at risk of getting shingles when older, whereas there is
no evidence that a chickenpox vaccination does."
Actually, here are just a few peer-reviewed studies documenting cases of
shingles following varicella vaccination.
Matsubara K, Nigami H, Harigaya H, Baba K. Herpes zoster in a normal child after
varicella vaccination. Acta Paediatr Jpn 1995 Oct; 37(5):648–50.
Hammerschlag MR, Gershon AA, Steinberg SP, Clarke L, Gelb LD. Herpes zoster in
an adult recipient of live attenuated varicella vaccine. J Infect Dis, 1989
Sept; 160(3):535–7.
Uebe B, Sauerbrei A, Burdach S, Horneff G. Herpes zoster by reactivated vaccine
varicella zoster virus in a healthy child. Eur J Pediatr, 2002 Aug;
161(8):442–4.
A 27-month-old girl developed an impressive herpes zoster infection 16 months
after varicella vaccination that was localized in three adjacent cervical
dermatomes. VZV vaccine stain was identified by polymerase chain reaction.
Naseri A, Good WV, Cunningham ET Jr. Herpes zoster virus sclerokeratitis and
anterior uveitis in a child following varicella vaccination. Am J Ophthalmol,
2003 Mar; 135(3):415–7.
Binder NR, Holland GN, Hosea S, Silverberg ML. Herpes zoster ophthalmicus in an
otherwise-healthy child. J AAPOS, 2005 Dec; 9(6):597–8.
A case of pediatric herpes zoster ophthalmicus in a child that had been
vaccinated against varicella and otherwise had no known exposure to varicella-zoster
virus and the initial presentation of HZO was a painful and diffuse
subconjunctival hemorrhage that appeared before any of its classic signs were
observed.
Kohl S. Rapp J, La Russa P, Gershon AA, Steinberg SP. Natural varicella-zoster
virus reactivation shortly after varicella immunization in a child. Pediatr.
Infect. Dis J. 1999 Dec;18(12):1112–3.
Twelve days following varicella vaccination in his right arm, a 6-year-old male
developed wild-type herpes zoster rash on his back and left arm.
Levin MJ, Dahl KM, Weinberg A, Giller R, Patel A, Krause PR. Development of
resistance to acyclovir during chronic infection with the Oka vaccine strain of
varicella-zoster virus, in an immunosuppressed child. J Infect Dis. 2003 Oct
1;188(7):954–9.
A 1-year-old boy was vaccinated with the Oka strain of varicella just prior to
the discovery of a tumor that required intensive antitumor therapy. Three months
later he developed herpes zoster, which developed into chronic verrucous lesions
that were refractory to treatment with acyclovir and which subsequently
disseminated. DNA from a biopsy specimen of a chronic herpes-zoster lesion
indicated that the Oka vaccine strain of the virus caused this severe
complication. Analysis of this viral DNA demonstrated a mutation in the viral
thymidine kinase gene. Plasmids containing this altered gene were unable to
produce functional thymidine kinase in an in vitro translation system. The
presence of this mutation would explain the clinical resistance to acyclovir.
This is the first report of Oka-strain varicella virus causing severe disease
after reactivation and of resistance to acyclovir during an infection caused by
this virus.
Ota K, Kim V, Lavi S, Ford-Jones EL, Tipples G, Scolnik D, Tellier R.
Vaccine-strain varicella zoster virus causing recurrent herpes zoster in an
immunocompetent 2-year-old. Pediatr Infect Dis J. 2008 Sep;27(9):847–8.
Varivax III is a live attenuated vaccine against varicella zoster virus (VZV).
The authors report “a case of recurrent vaccine-strain herpes zoster in an
immunocompetent 2-year-old child.” This report aims to alert physicians that
recurrent vaccine-strain herpes zoster can be a rare complication of VZV
vaccination in apparently immunocompetent hosts.
Iyer S, Mittal MK, Hodinka RL.Herpes Zoster and Meningitis Resulting From
Reactivation of Varicella Vaccine Virus in an Immunocompetent Child. Ann Emerg
Med. 2008 Nov 22.
Herpes zoster complicated by meningitis has been mainly reported in
immunocompromised patients after reactivation of wild-type varicella-zoster
virus. We present one of the first cases of aseptic meningitis after herpes
zoster caused by reactivation of vaccine-type varicella-zoster virus in an
immunocompetent child. We also highlight the increasing role of both wild-type
and vaccine strains of varicella-zoster virus as a cause of viral
meningoencephalitis and the use of appropriate laboratory tools to rapidly and
accurately identify the virus in order to provide prompt patient care and
management.
Here are some first-hand experiences sent referred to me directly:
On November 5, 2007, parents of a daughter with shingles wrote Dr. Goldman:
“A friend of mine e-mailed me a link to an article you had written regarding the
chickenpox vaccine. Our oldest daughter who is only 16 recently suffered from
her second bout with shingles. She first had an episode of shingles at the age
of 13. Our daughter NEVER had chickenpox, but was given the varicella vaccine in
1995. We were never told or even warned that it could cause shingles. We find it
unbelievable that the ‘solution’ we are being provided is to go to the
Infectious Disease Department at a local University Hospital in order to have
them ‘help us manage’ this for the rest of our daughter’s life. Now we have to
remedy the shingles and we are altogether convinced that there will be many,
many other young people adversely affected by what is a dangerous vaccine with
awful side affects that stay with you for a lifetime...far worse than chickenpox
in one’s youth. Our daughter missed a week of school each time and suffered
incredibly....”
On September 22, 2008, a nurse telephoned Dr. Goldman to report the following:
“My son, who had natural chickenpox at 3 years of age, and who is now 16 years
old, has been recovering for the past 6½ months from herpes zoster (with a rash
in the T1 dermatome). He experienced vomiting and severe headaches that lead to
a diagnosis of viral meningitis from central nervous system (CNS) complications
of herpes zoster.”
Interestingly, the nurse indicated that the physician treating her son had
encountered another teen with the same diagnosis a week prior to her son’s case.
Sincerely,
Gary S. Goldman, Ph.D.
Gary Goldman
Nov. 1, 2009 at 12:15am
Varicella (chickenpox) and herpes zoster (shingles) both develop from the same
varicella-zoster virus (VZV). As varicella vaccination became more widespread,
incidence of shingles among adults has nearly doubled. This is due to an
immunologically-mediated link between varicella and herpes zoster. Adults used
to receive a natural boost from children with chickenpox in the community. This
boosted the adults' cell-mediated immunity to help suppress or postpone the
reactivation of herpes zoster.
Summary statement regarding the Universal Varicella Vaccination Program
Prior to the universal varicella vaccination program, 95% of adults experienced
natural chickenpox (usually as school age children)these cases were usually
benign and resulted in long term immunity. This high percentage of individuals
having long term immunity has been compromised by mass vaccination of children
which provides at best 70 to 90% immunity that is temporary and of unknown
durationshifting chickenpox to a more vulnerable adult population where
chickenpox carries 20 times more risk of death and 15 times more risk of
hospitalization compared to children. Add to this the adverse effects of both
the chickenpox and shingles vaccines as well as the potential for increased risk
of shingles for an estimated 30 to 50 years among adults. The Universal
Varicella (Chickenpox) Vaccination Program now requires booster vaccines;
however, these are less effective than the natural immunity that existed in
communities prior to licensure of the varicella vaccine. Routine vaccination
against chickenpox has produced continual cycles of treatment and disease.
Gary Goldman
************
"It turns people into pathogen carriers and provides viruses with convenient
hiding places."
"But among pregnant women, who can go to the front of that line, three-fourths
aren’t getting vaccinated,"
http://www.sciencenews.org/view/generic/id/48976/title/From_the_infectious_diseases_meeting_Whats_with_the_vaccine-o-phobia%3F
From the infectious diseases meeting: What's with the
vaccine-o-phobia?
Science News writer Nathan Seppa talks with physicians about people
opting out of vaccinations
By
Nathan Seppa
Web edition : 2:09 pm
Text Size
PHILADELPHIA - For the folks who promote vaccination, these are trying times.
Recently, CNN hosted a segment titled: “Virus or Vaccine: Which is Worse?”
It’s enough to set Paul Offit to ranting, which he did this week at a meeting of
the Infectious Diseases Society of America. Offit, a physician who heads the
infectious disease division at Children’s Hospital of Philadelphia, has devoted
a career to fighting illness. In his job, vaccines are often the most reliable
weapon available, and cost-effective to boot. And although it’s astonishingly
more dangerous to contract a disease than it is to get vaccinated for it, that
message seems to have gotten lost somewhere along the way.
Offit traces this detour back to 1982, when DPT the shot that prevents
diphtheria, tetanus and pertussis – was (wrongly) linked to brain damage. “Three
people believed their kids were harmed by the vaccine,” he says.
Offit has compassion for families who have a child who has suffered, whatever
the cause may be, known or unknown. But since 1982, it’s been one accusation
after another against vaccines. People tried to link the HIB vaccine to diabetes
(no evidence), the hepatitis B vaccine to multiple sclerosis (all but one study
found no link), and other vaccines to SIDS or autism. Recently, the HPV vaccine
which prevents cervical cancer – got linked to heart attacks and strokes (no
proof).
And now the seasonal flu vaccine and H1N1 flu vaccine are being skipped by
millions of people who somehow distrust the science that went into making them,
even though the illnesses they cause can be fatal.
But hey, it’s a free country. Paul Offit just throws up his hands: “Is it your
right to catch and transmit a potentially fatal infection? The answer is ‘yes,’”
he says.
Mary Ann Jackson, a physician who heads the infectious disease section at
Children’s Mercy Hospitals and Clinics in Kansas City, Mo., investigates
vaccination rates among specific groups. She says that the new generation of
people dodging vaccines includes many white, college-educated women, often young
mothers who get their information from the Internet. The odd part, Jackson says,
is that these same women are also health-conscious, seat-belt-buckling folks.
“They are trying to choose what’s best for their children. They want it to be
their own decision,” she says.
Unfortunately, avoiding vaccination has consequences beyond one household. It
turns people into pathogen carriers and provides viruses with convenient hiding
places. “Herd immunity is eroding to the point that we’re now seeing outbreaks
of preventable diseases,” says Offit. In 2004, for example, the United States
experienced its worst outbreak of whooping cough (pertussis) in years. Mumps has
also cropped up. Daycares have become high-risk areas because they’ve got a
population of children who are relatively under-vaccinated, he says. “Doctors
are worried about their waiting rooms being dangerous places.”
William Schaffner, a physician who chairs the Department of Preventive Medicine
at Vanderbilt University, cited a recent round of focus groups held to discuss
vaccines. Some people voiced doubts about vaccine safety. But Schaffner was
impressed by one group of participants who were adamantly in favor of
vaccination: immigrants from developing countries. “They knew about these
diseases,” he says.
Meanwhile, infectious disease experts have little use for “natural exposure”
adherents, which include parents who have been known to host chickenpox parties
or who otherwise intentionally expose their children to a disease rather than
get the kids vaccinated. Chickenpox is far from harmless. While most cases in
young children are indeed benign, older children and adults can get terrible
illnesses. And getting chickenpox as a child puts a person at risk of getting
shingles when older, whereas there is no evidence that a chickenpox vaccination
does.
It’s easy to see why these scientists get frustrated. But sometimes not even a
barrage of facts helps their cause. Ronald Reagan famously said, “Facts are
stupid things.” Maybe so, maybe no.
For example, the vaccine for H1N1 flu is now being distributed nationwide. But
among pregnant women, who can go to the front of that line, three-fourths aren’t
getting vaccinated, even though H1N1 is particularly lethal for them and as if
that weren’t enough it poses risks to theirs fetuses. Facts are scary things.
Health-care workers, another bunch who should know better, also don’t
necessarily get vaccinated. Jackson was shocked to find flu vaccination rates of
only 50 percent among hospital workers she studied.
So despite vaccines’ overwhelming safety profile when compared to the risks run
by exposure to the diseases they prevent, and despite the exhortations of the
CDC and World Health Organization, some people just gravitate toward other
sources of information they deem more reliable.
"There’s a post-modernist notion that all levels of belief are acceptable,”
Offit says.
The vaccine disconnect brings to mind a bumper sticker seen a few years ago,
when some school boards and even the state of Kansas were openly advocating the
teaching of an alternative explanation to counter Darwin’s theory of evolution.
The bumper sticker read: “What’s next gravity?”