Edmonston measles vaccines

Edmonston measles vaccines
Measles vaccines

http://www.egroups.com/message/evolutionary-psychology/7316
http://www.cdc.gov/epo/mmwr/preview/mmwrhtml/00053391.htm
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"Since 1963, when both inactivated and live attenuated (Edmonston B strain) vaccines were licensed, the type of measles vaccine used in the United States has changed several times. Distribution of the inactivated and live Edmonston B vaccines ceased after 1967 and 1975, respectively. Distribution in the United States of a live, further attenuated vaccine (Schwarz strain) first introduced in 1965 has also ceased. A live, further attenuated preparation of the Enders-Edmonston virus strain that is grown in chick embryo fibroblast cell culture, licensed in 1968, is the only measles virus vaccine now available in the United States. This further attenuated vaccine (formerly called "Moraten") causes fewer adverse reactions than the Edmonston B vaccine. "
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"Live attenuated Edmonston B measles vaccine (distributed from 1963 to 1975) was usually administered with IG or high-titer measles immune globulin (MIG; no longer available in the United States). Vaccination with this product, administered on or after
the first birthday, is considered an effective first dose of vaccine. If indicated, a second dose of MMR vaccine should be administered (see Documentation of Immunity). "<SNIP>

"The vaccine virus strain has been attenuated beyond the level of the original Edmonston B strain and is therefore known as a further attenuated strain. Vaccine prepared with the further attentuated measles virus causes fewer reactions than its predecessor, Edmonston B vaccine, which is no longer distributed in the United States."--ACIP/CDC 1982 http://www.cdc.gov/epo/mmwr/preview/mmwrhtml/00001090.htm