Mycoplasma
Vaccine contaminants
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Kojima A, Takahashi T, Kijima M, Ogikubo Y, Tamura Y, Harasawa R. Detection of mycoplasma DNA in veterinary live virus vaccines by the polymerase chain reaction. J Vet Med Sci 1996 Oct;58(10):1045-8. PMID 8916012.
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Thornton
DH. A survey of mycoplasma detection in veterinary vaccines.Vaccine. 1986 Dec;4(4):237-40.PMID: 3799018 [PubMed - indexed for MEDLINE
Nine live virus veterinary vaccines from six sources were found to be contaminated with
mycoplasma. The vaccines were for use in canine, feline and avian species, and 53 batches
of the products were at fault. The isolates were identified as Mycoplasma hominis, M.
arginini, M. orale, M. hyorhinis and M. gallinarum. Investigation of the contamination
rate of other batches or other products from the same source in some cases helped to
determine the source of infection. Mycoplasma contaminants can be considered important not
only because of their role as pathogens but also because they may indicate that
insufficient care has been taken during vaccine manufacture or quality control.