DIPHTHERIA AND TETANUS TOXOIDS ADSORBED (DT Adsorbed) |
Connaught |
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Vaccine |
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Indications: For the primary immunization of infants, at or above the age of
2 months, and of preschool children against diphtheria and tetanus in whom
simultaneous immunization against pertussis is not indicated. |
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Contraindications: Infants or children with fever, or other evidence of acute
illness. |
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Elective immunization of individuals over 6 months of age should be deferred
during an outbreak of poliomyelitis. |
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The vaccine should not be administered to older children (after 6 years of age)
nor to adults because of the danger of reactions to diphtheria toxoid. |
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Warnings: Individuals receiving corticosteroids or other immunosuppressive
drugs may not develop an optimum immunologic response. |
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Precautions: The possibility of allergic reactions in individuals sensitive to
the components of the product should be borne in mind. |
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Epinephrine HCl solution 1:1 000 should be available for immediate use in
case an anaphylactic or acute hypersensitivity reaction occurs. |
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Frequent booster doses of tetanus toxoid in the presence of adequate or excessive
serum levels of tetanus antitoxin have been associated with increased incidence and
severity of reactions and should be avoided. If hypersensitivity to the diphtheria
component is suspected, tetanus toxoid should be used for reinforcing doses. |
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A separate sterile syringe and needle or a sterile disposable unit should be used for
each individual patient to prevent the transmission of hepatitis or other infectious
agents. |
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Adverse Effects: Mild local reactions consisting of pain, erythema, tenderness
and induration at the injection site are common, and may be associated with systemic
reactions including mild to moderate transient fever and irritability. |
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Persistent nodules at the site of injection have occurred following the use of an
adsorbed product, but this complication is unusual. |
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Dosage: For primary immunization of infants, it is recommended that 3 i.m.
injections of 0.5 mL be administered at 2, 4 and 6 months of age, followed
by a fourth dose (0.5 mL) 1 year after the third dose, or at 18 months of
age. |
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Although it is recommended that immunization be started at 2 to 6 months of
age, if for any reason it is delayed, a similar schedule (3 doses with an interval of
2 months between doses, followed by a fourth dose 1 year after the third dose),
may be used throughout the preschool period. |
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A reinforcing injection of 0.5 mL i.m. should be administered between 4 and
6 years of age (i.e., at the time of school entry). This booster is not necessary if
the fourth primary immunizing dose has been administered after the fourth birthday. |
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Supplied: Each 0.5 mL dose contains: diphtheria toxoid (25 Lf.)
tetanus toxoid (5 Lf.) and aluminum phosphate 1.5 mg. Thimerosal 0.01% is added
as a preservative. Rubber stoppered vials of 5.0 mL and glass ampuls of 0.5 mL
(1 dose). Store at 2 to 8°C. Do not freeze. Product exposed to freezing should
not be used. |