Citations: death &
vaccination
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VACCINATION DEATHS
Citations
Arevalo, "Vaccinia Necrosum. Report on a Fatal Case", Bol Ofoc Sanit Panamer, Aug 1967, 63:106-110.
Apostolov. et al, "Death of an Infant in Hyperthermia After Vaccination", J Clin Path, Mar 1961, 14:196-197.
Aragona, F, "Fatal Acute Adrenal Insufficiency Caused by Bilateral Apoplexy of the Adrenal Glands (WFS) following Anti-poliomyelitis Vaccination", Minerva Medicolegale, Aug 1960; 80:167-173.
Belsher JL et al. Fatal
multiorgan failure due to yellow fever vaccine-associated viscerotropic disease.Vaccine.
2007 Dec 5;25(50):8480-5. Epub 2007 Sep 18. PMID:
18023511 [PubMed - indexed for MEDLINE]
Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare
complication of yellow fever (YF) vaccination. A previously healthy 22-year-old
female died following YF vaccination despite aggressive measures. Serial
viral load titers, cytokine levels and host genetic factors were evaluated in an
attempt to understand this unusual and lethal outcome. The patient's high-titer
vaccine viremia and possibly related minor genetic anomalies provide clues to
exploring the etiology of YEL-AVD.
Bouvier-Colle, MH, "Sex-Specific Differences in Mortality After High-Titre Measles Vaccination", Rev Epidemiol Sante Publique, 1995; 43(1): 97.
Baraff, LJ, et al, "Possible Temporal Association Between Diphtheria-tetanus toxoid-Pertussis Vaccination and Sudden Infant Death Syndrome", Pediatr Infect Disorder, Jan-Feb 1983, 2(1): 5-6.
Chan RC, et al. Hepatitis and death following vaccination with
yellow fever 17D-204 vaccine. Lancet 2001;358:121-122.
Died 8 to 11 days after vaccination
Connolly, J H, Dick, G W, Field, CM, "A Case of Fatal Progressive Vaccinia", Brit Med Jour, 12 May 1962; 5288:1315-1317.
Ehrengut W, et al. [On fatal cases within 4 weeks following smallpox vaccination]. Dtsch Med Wochenschr. 1966 Dec 30;91(52):2339-42. German. No abstract available.PMID: 5926732; UI: 67049747.
Flahault A, "Sudden infant death syndrome and diphtheria/tetanus toxoid/pertussis/poliomyelitis immunisation.", Lancet 1988 Mar 12;1(8585):582-583.
Fulginiti, V, "Sudden Infant Death Syndrome, Diphtheria-Tetanus Toxoid-Pertussis Vaccination and Visits to the Doctor: Chance Association or Cause and Effect?", Pediatr Infect Disorder, Jan-Feb 1983, 2(1): 7-11.
Goetzeler, A, "Fatal Encephalitis after Poliomyelitis Vaccination", 22 Jun 1961, Muenchen Med Wschr, 102:1419-1422.
Jennings AD, et al. Analysis of a yellow fever virus isolated from a fatal case of vaccine-associated human encephalitis. J Infect Dis. 1994 Mar;169(3):512-8. PMID: 7908925; UI: 94209744.
Keenlyside
RA, et al. Fatal Guillain-Barre syndrome after the national influenza immunization
program. Neurology. 1980 Sep;30(9):929-33. PMID: 6252515; UI: 81031247.
Fifty-eight fatal cases of Guillain-Barre syndrome (GBS) were reported during the 1976 to
1977 National Influenza Program: Thirty-two (58%) of these patients had received the A/New
Jersey influenza vaccine. The mean interval from vaccination to onset was 3.9 weeks, and
the incidence of preceding illness in vaccinated or unvaccinated patients was similar.
Fifty-eight percent had at least one chronic disease before onset. The clinical features
were similar in vaccinated and unvaccinated patients. Most deaths followed medical
complications of respiratory paralysis: Fifteen had pneumonia, 29 (83%) died suddenly, 15
had sudden arrhythmias or hypotension, and 7 had myocardial infarction or pulmonary
embolus.
Larbre, F et al, "Fatal Acute Myocarditis After Smallpox Vaccination", Pediatrie, Apr-May 1966, 21:345-350.
Larbre F, et al. [See Related Articles] [Fatal acute myocarditis after smallpox vaccination]. Pediatrie. 1966 Apr-May;21(3):345-50. French. No abstract available.PMID: 5930422; UI: 66123132.
Labauge R, et al. Postvaccinal encephalitis in adult. A case with anatomo-clinical report. Rev Neurol (Paris). 1979;135(11):803-13. French. PMID: 45321; UI: 81125716.The case reported concerns a man of 27 years who presented 10 days after a polyvaccination (7 vaccines in 2 months) altered consciousness, epileptic fits, right hemiplegia, vegetative dysfunctions and meningeal status. Evolutionary clinical course led to death in 21 days.
16 cases of neurological disease and/or death shortly after pertussis immunization are reported. Eight patients had convulsions, six with ensuing permanent defects. Severe polymyositis was observed in one case. Five infants died 12 h to 4 days after vaccination: two after acute encephalopathy and three in the form of a sudden unexpected death (SID). In two fatal cases the morphological changes in the brain corresponded to those of pertussis encephalopathy: neuronal degeneration in various parts of the cortex, especially in the region of the ammons horn, and in the cerebellum. There were no signs of inflammation. Three cases underwent forensic autopsy and death was attributed to bronchopulmonary infection. Complete neuropathological work-up was only done in one case, in which the brain was normal. The critique of episodical reports and the demand for prospective studies is appreciated. Knowledge of all possible forms of complications, however, is indispensable for future investigations. Polymyositis and SID have so far not been listed as abnormal reactions to immunization. The majority of our cases became known accidentally from hospital sheets or from discussions with collegues. For a detection of all possible cases a greater awareness of doctors for the problem of pertussis immunization appears necessary. Only another 23 cases have been reported to the health authorities of the state of Lower Saxony during the last 6 to 7 years. Of those, nine were either harmless reactions or diseases probably unrelated to vaccination. Two were cases of SID, 12 and 72 h after vaccination. It is concluded that only a minor proportion of possible complications is presently reported to the health authorities.
Mittermayer CH.Lethal complications of typhoid-cholera-vaccination. (Case report and review of the literature).Beitr Pathol. 1976 Jul;158(2):212-24.PMID: 985298; UI: 77044468
Na, "DPT Vaccination and Sudden Infant Death - Tennessee, US Dept HEW, MMWR Report, Mar 23, 1979, vol 28(11): 132.
No authors listed] Fatal viral encephalitis following 17D yellow fever vaccine inoculation. Report of a case in a 3-year-old child. JAMA. 1966 Nov 7;198(6):671-2. No abstract available.PMID: 4380787; UI: 67043249.
Oyelami SA, et al. Severe post-vaccination reaction to 17D yellow fever vaccine in Nigeria. Rev Roum Virol. 1994 Jan-Jun;45(1-2):25-30. PMID: 7756161; UI: 95275719.
Reynolds, E, "Fatal Outcome of a Case of Eczema Vaccinatum", Lancet, 24 Sept 1960, 2:684-686.
Rocchi
G, Giannini V, Provvidenza G, Andreoni G. [Poliomyelitis due to
poliovirus 3, with fatal outcome in an infant vaccinated with Sabin vaccine] G Mal Infett Parassit. 1967 Jul;19(7):463-5. Italian. No abstract available.PMID:
4303743 [PubMed - indexed for MEDLINE]
Romanov
VA, Bereshkova RV. Zh Mikrobiol Epidemiol Immunobiol 1975 Jun;(6):66-72
[Pathomorphological and immunofluorescent studies of smallpox vaccine neurotropism].
[Article in Russian]
Experiments were conducted on guinea pigs sensitized with the AK C-vaccine components. In
intracardiac injection with smallpox vaccine there was shown a possibility of development
of marked hemodynamic disturbances, of the inflammatory-dystrophic processes of
irreversibel character, with a subsequent neuronophagia and demyelinization. Injection of
smallpox vaccine into the circulation of intact guinea pigs was accompanied by development
in the nervous system of insignificant circulatory disturbances and of the inflammatory
dystrophic phenomena of reversible character. A method of immunofluorescence was used and
the antigen of the vaccine virus was revealed in the neurons of the brain and the spinal
cord of the sensitized and intact animals. Marked hemodynamic and insignificant
inflammatory-dystrophic processes were revealed in the nervous system of a child which
died of the post-vaccinal encephalitis; an antigen of the smallpox virus was found by the
immunofluorescent method in the nerve cells and the vessels in various portions of the
nervous system. PMID: 239507, UI: 75221294
Rasch DK, et al. Fatal disseminated infection due to poliovirus type 2 vaccine. Am J Dis Child. 1986 Dec;140(12):1211-2. No abstract available.PMID: 3776928; UI: 87045970
Sindern E, Schroder JM, Krismann M, Malin JP. Inflammatory polyradiculoneuropathy with spinal cord involvement and lethal outcome after hepatitis B vaccination. Neurologische Klinik, BG-Kliniken Bergmannsheil, Ruhr-Universitat, Burkle-de-la-Camp-Platz 1, 44789, Bochum, GermanyStewart GT, "Deaths of infants after triple vaccine.", Lancet 1979 Aug 18;2(8138):354-355.
Schwebke D, et al. [Clinical and EEG course observations in postvaccinal encephalitis with fatal outcome]. Kinderarztl Prax. 1974 Jul;42(7):307-12. German. No abstract available.PMID: 4155459; UI: 75080434.
Trip JA. [Vaccinate and die]? Ned Tijdschr Tandheelkd. 1983 Nov;90(11):537-40. Dutch. No abstract available.PMID: 6583530; UI: 84142463.
Toro G, Vergara I, Roman G. Neuroparalytic accidents of antirabies vaccination with suckling mouse brain
vaccine. Clinical and pathologic study of 21 cases.
Arch Neurol. 1977 Nov;34(11):694-700.
PMID: 911231 [PubMed - indexed for MEDLINE
Twenty-one cases of
neuroparalytic accidents of rabies vaccination (with suckling mouse brain
vaccine), 11 of them fatal, were observed, occurring predominantly in men; the
mean age of the patients was 29 years. On the average, 13 doses of the vaccine
were used. Only three patients received less than seven doses. The mean latent
period was 14 days (range, 4 to 24 days). In 16 patients (76%), a
Guillain-Barre syndrome occurred that was moderate in three, severe in seven,
and fatal in six. Pathologically, this was shown to be a typical
polyradiculoneuritis. Five patients had fatal involvement of the central
nervous system. Three had an acute disseminated perivenous
leukoencephalopathy, with concurrent rabies encephalitis in one case. One
patient had a perivenous myeloradiculopathy and one a chronic
encephalomyelopathy of six years' duration with demyelinating plaques in the
periventricular white matter, cerebellum, and spinal cord. Since the reduction
of postexposure rabies vaccination to seven doses, no new cases have been
observed in Colombia. PMID: 911231 [PubMed -
indexed for MEDLINE]
Vasconcelos PFC, et al. Serious adverse events associated with
yellow fever 17DD vaccine in Brazilia report of
two cases. Lancet 2001;358:91-97.
Two Brazilian citizens (age 5 and 22 years) became
ill three to four days after receiving 17DD vaccine in Brazil,
all of whom died 8 to 11 days after vaccination.
[Vaccination] [Deaths]