[back] Vaccination and pregnancy
Vaccine Information For Pregnant Women
Joanna 6 months pregnant with Yanny
http://www.vaccineriskawareness.com/Vaccine-Information-For-Pregnant-Women
No Pregnant Woman Died From Respiratory Illness and Women Vaccinated Against Flu Had The Same Risk For Flu As Unvaccinated Women
The Advisory Committee on Immunization Practices of the Centers for Disease
Control and Prevention recommends influenza vaccination for women who will be in
the second or third trimester of pregnancy during the influenza season. We
analyzed hospital admissions with principal diagnoses of influenza or pneumonia
and influenza-like illness (ILI) outpatient visits to study the effectiveness of
influenza vaccine during pregnancy in protecting women and infants from
influenza-related morbidity. Estimates of influenza vaccine effectiveness across
five flu seasons (Fall 1997 to Spring 2002) were calculated using Cox
proportional hazards models for women and infant study populations in Kaiser
Permanente Northern California. Outpatient utilization outcomes included
physician visits with a diagnosis of upper respiratory infection, pharyngitis,
otitis media, asthma, bronchial asthma, viral infection, pneumonia, fever,
cough, or wheezing associated with respiratory illness. Inpatient outcomes
included hospitalizations with principal diagnoses of influenza or pneumonia.
Women who received influenza vaccine during pregnancy had the same risk for ILI
visits compared with unvaccinated women, adjusting for women's age and week of
delivery. When asthma visits were excluded from the outcome measure, we also
found no difference in the risk of outpatient visits for vaccinated and
unvaccinated women. Hospital admissions for influenza or pneumonia for women in
the study population were quite rare and no women died of respiratory illness
during pregnancy. Infants born to women who received influenza vaccination had
the same risks for influenza or pneumonia admissions compared with infants born
to unvaccinated women, adjusting for infant's gender, gestational age, week of
birth, and birth facility. Maternal influenza vaccination was also not a
significant determinant of risk of ILI (excluding otitis media) outpatient
visits for infants, nor did it significantly affect the risk of otitis media
visits. Influenza vaccination during pregnancy did not significantly affect the
risk of cesarean section, adjusting for the woman's age. It also did not affect
the risk of preterm delivery. Although the immunogenicity of influenza
vaccination in pregnancy in mother and infant has been well documented, in this
study, we were unable to demonstrate the effectiveness of influenza vaccination
with data for hospital admissions and physician visits. One possible
interpretation of these findings is that typical influenza surveillance measures
based on utilization data are not reliable in distinguishing influenza from
other respiratory illness. Hospitalizations for respiratory illness were
uncommon in both vaccinees and nonvaccinees.
Source: Am J Perinatol. 2004 Aug;21(6):333-9.
Vaccination During Pregnancy Does Not Prevent Respiratory Illness in Newborns
OBJECTIVE: To determine whether influenza vaccination of pregnant women
prevents visits for respiratory illness in their infants born during the
influenza season. DESIGN: Retrospective matched cohort study. SETTING: Four
managed care organizations in the United States. Patients A total of 41 129
infants (3160 and 37 969 born to vaccinated and unvaccinated mothers,
respectively) born between 1995 and 2001. Main Exposure Maternal influenza
vaccination. Infants were considered exposed if their gestational age at birth
was at least 30 weeks, if the time from maternal vaccination to birth was at
least 28 days, and if they were exposed to at least 14 days of the influenza
season. MAIN OUTCOME MEASURES: Incidence of acute respiratory illnesses
(outpatient, emergency department, and inpatient settings combined) and incident
rate ratios (IRRs) for infants exposed and unexposed to maternal vaccination
during the following 4 periods: peak influenza, respiratory syncytial virus
predominant, periseasonal, and summer weeks. The time to the first acute
respiratory illness during peak influenza weeks was also assessed. RESULTS:
During the peak influenza weeks, infant visit rates were 15.4 and 17.1 per 100
person-months for exposed and unexposed infants, respectively (IRR, 0.90; 95%
confidence interval, 0.80-1.02). Adjusted IRRs for the 4 periods found a
protective effect of infant female sex, whereas Medicaid status and maternal
high-risk status increased infant visit rates. Maternal influenza vaccination
did not reduce visit rates during any of the 4 time periods (IRR for peak
influenza season, 0.96; 95% confidence interval, 0.86-1.07) and did not delay
the onset of first respiratory illness. CONCLUSION: We were unable to
demonstrate that maternal influenza vaccination reduces respiratory illness
visit rates among their infants.
Source: Arch Pediatr Adolesc Med. 2006 Dec;160(12):1277-83.
Autism in Children Born to Mothers Who Were Vaccinated in Pregnancy
Autism may be triggered by MMR vaccine in a subgroup of children genetically
predisposed to immunological problems, new unpublished research suggests. The
research has led to a hypothesis that mothers who fail to develop protective
antibodies when they themselves are vaccinated with MMR may have an immune
problem which predisposes their children to autism. The study postulates that
autism might then be triggered by an ‘immune insult’ like giving MMR or another
live vaccine to the child. Alternatively, a live vaccine booster, given
inadvertently to the mother during pregnancy, could cause autism via a
teratogenic effect on the fetus. The hypothesis has been described as
biologically plausible by a former medical assessor to the UK Committee on
Safety of Medicines and a key official at the US Center for Disease Control.
Dr Edward Yazbak, a retired US paediatrician, has presented preliminary results
of his study to a conference of the authoritative American Academy of
Pediatrics.
The controversial findings are due to be published later this year. Dr Yazbak
contacted 400 members of vaccine and parent groups using the internet and
newsletters in the UK, Australia and the US. He asked all mothers who had
received an MMR or rubella booster after the age of 16, because of a failure to
seroconvert to an earlier dose, to complete a questionnaire.
His final results reveal that among women revaccinated with MMR or any other
live vaccine just before, during or after pregnancy, 76 per cent had one or more
child diagnosed with autism spectrum disorders.
A further 17 per cent of these women went on to have children with autistic
tendencies, severe attention deficit hyperactivity disorder and significant
developmental delays.
Dr Yazbak said: ‘The vaccine from the mother and the immune predisposition of
the mother are predisposing factors for the child.
‘Then the child has its own vaccine which is a precipitating factor - except
where the mother is revaccinated (during or before conception) when the child is
damaged from birth.’
He added: ‘This is a very unscientific study. I’m just saying “listen, this is
something worth pursuing”.
Dr Peter Fletcher, who was principal medical officer and medical assessor to the
CSM during the 1970’s, said the hypothesis was plausible. He said: ‘It’s
certainly something the immunologists should have a better look at.’
Dr Robert Chen, chief of vaccines safety and development at the US National
Immunisation Programme at the Center for Disease Control said: ‘It’s an
interesting hypothesis in the sense that wild rubella is known to be one of the
risk factors of autism. This is one of the true causes of autism, which has been
well documented.’
But he said this would not explain why the same effect may be seen in women
revaccinated soon after giving birth.
Dr Yazbak said one explanation might be that the viruses from vaccines could be
passed to the infant via breast milk.
Source: Pulse doctor's magazine, 7th July 2001 edition.
ABSTRACT
We identified 60 rubella-susceptible mothers who were revaccinated in the
postpartum period with either the measles-mumps-rubella (MMR) or the monovalent
rubella vaccine and whose children later received MMR vaccine. Forty-five of
these women have children diagnosed with autistic spectrum disorder (ASD);
another ten women have children with autistic symptoms, ADD/ADHD or other
developmental delays; and four women have children with other health problems,
mostly immunologic. These outcomes raise concerns about the practice of
postpartum vaccination and suggest that an immune mechanism may increase
children's susceptibility to ASD.
Background
Although parents continue to report that their previously typical children begin
to display symptoms of autism and lose previously acquired skills after
receiving routine childhood immunizations (particularly the MMR vaccine), the
medical community has tended to discount the possibility of a link between
autism and vaccination. Most medical researchers, in fact, completely dismiss
such "anecdotal evidence" as scientifically invalid. While it is true that
parents have only the observations of their own children to rely on, there can
be no closer monitoring of a child than that done by its own parent. To ignore
the information provided by parents of autistic children as desperate
conclusions drawn by grieving individuals is pretentious and overlooks
potentially valuable data.
Women are routinely tested for rubella immunity before marriage, and those
susceptible are promptly vaccinated if they are not pregnant. The Center for
Disease Control and Prevention (CDC) recommends that women be tested again at
the time of their first obstetrical visit, and that those found to lack rubella
immunity be vaccinated in the postpartum period. The vaccine manufacturer states
that it has been found "convenient" to vaccinate women in the postpartum period,
but adds that "caution should be exercised." The monovalent rubella vaccine was
used exclusively in the past. Lately, the MMR vaccine, on the recommendation of
the CDC, has largely replaced it.
The intent of this study was to examine what effect the mothers' revaccination
during the postpartum period may have had on their children.
Methods
The questionnaire reproduced in Appendix A was distributed by e-mail and
newsletter to parent groups in the United Kingdom, Australia, and the United
States and posted on several web sites. The study was also mentioned in a
popular book on autism(1) and in publications by the Autism Research Institute
and the Autism Autoimmunity Project. A total of 440 questionnaires had been
received by the time of this analysis. Each entry was assigned a number, and an
immediate effort was made to contact the mother to notify her of her study
number and to complete any missing information. Questionnaires were excluded if
they were incomplete and contact information was not supplied: about 70
questionnaires had to be discarded for this reason. Of the remaining 370
respondents, sixty had received MMR or rubella vaccine in the postpartum period
and were included in this study. All questionnaires are available for review,
and the data from the 60 subjects of this report are available in digital
format.
Selected Case Presentations
1. Although this patient, a psychologist, born in 1958, had measles and rubella
as a child, she was found to be rubella-susceptible when she was pregnant in
1984, 1986, 1992, and 1998. She received no vaccines following the first three
pregnancies. Her two older children (a boy, age 16, and a girl, age 13) are
healthy. A third infant died at age 2 days from prematurity-related
complications. After her fourth pregnancy, the mother received MMR vaccine in
the immediate postpartum period. The baby was breast-fed beyond 18 months of
age. In the first year of life, he was severely constipated and had three "viral
illnesses with generalized exanthems." He was immunized on the recommended
schedule and received his first MMR at the age of 12 months. Prior to this time,
the boy had appropriate speech and above-average cognitive abilities, but he
stopped progressing after his first birthday and then went on to lose previously
acquired skills. A developmental evaluation done at a chronological age of 20
months revealed an approximate developmental age of 11-13 months (language,
motor and cognitive). Autistic symptoms are now apparent and a diagnosis of
autism is forthcoming. The mother developed severe arthritis of her knees,
ankles, and hips following her own vaccination.
2. Though she was vaccinated as a child, this patient, who was born in 1957 and
is afflicted with scleroderma, failed to develop protective rubella titers. In
1997, she delivered her first child, a son, and was given an MMR booster
postpartum. She became febrile and developed a rash but had no joint symptoms.
The boy, who was born at full term and was breast-fed, appeared bright, verbal,
and sociable during the first year of life. At the age of 15 months, he received
his first MMR. He reacted promptly with fever, irritability, and loose stools.
Shortly thereafter, he lost previously acquired speech and withdrew from social
contact. He currently has persistent diarrhea, sleep difficulties, and extensive
eczema. He has been diagnosed with ASD.
3. This mother, who had received all recommended immunizations, delivered her
first child, a girl, in 1984 and received rubella vaccine postpartum because she
had remained rubella-susceptible. The baby was not breast-fed and is normal.
After 3 miscarriages, the patient delivered a boy in September 1987, and
received another postpartum rubella vaccine because she still had no detectable
rubella immunity. The boy was breast-fed for 4 months and developed normally at
first. At the age of 29 months, he received his first MMR vaccine. He lost all
language by the age of 36 months and has now been diagnosed with autism. While
breastfeeding her third child, a girl, the mother received her third rubella
booster in four years, as she was still rubella-susceptible. The child has
severe dyslexia, serious learning disabilities, and ADHD.
4. This mother's first pregnancy resulted in a daughter who is now 22 years old,
in good health and attending college. Her second child, a boy, died at the age
of three months; the cause of death was listed as Sudden Infant Death Syndrome
(SIDS). After the birth of the third child, a boy, in 1979, she was told that
she had no immunity to rubella and was given MMR vaccine. The child was
breast-fed for six months and at first developed normally. He received his MMR
vaccine at age 15 months. By age 18 months, he developed chronic diarrhea,
stopped talking, and became withdrawn. He has been diagnosed with autism, after
an extensive work-up that was otherwise negative, including normal chromosomal
studies. Of the mother's subsequent children, one girl and four boys were
afflicted with learning disabilities, mental retardation, or pervasive
developmental disorder (PDD); one also had Tourette syndrome. The last child,
who was premature, had hypoplastic left heart syndrome and a single kidney. She
only lived two days. Family history was negative for autism, and the mother had
normal chromosomal studies.
5. Despite being vaccinated routinely, this mother, born in 1964, still
developed all three diseases: measles, rubella, and mumps. Because of a
diagnosis of "some immune problem," she received injections of gamma globulin
for a while. In 1983, she received an MMR vaccine because of an outbreak of
measles at college. In 1991, 1992, and 1997, she was found to be immune to
measles. She was also immune to rubella in 1991, when she was pregnant with her
first boy, who is in good health. During her second pregnancy, in 1992, she was
found to be rubella-susceptible. After she delivered, she was given yet another
MMR "that same day against my will." This boy, who was breast-fed, apparently
assumed a fetal position on the 4th day of life and screamed for 24 hours. He
was severely constipated through the first year of life but has had diarrhea
since then. He has been diagnosed with autism. A third child, a girl, is normal.
The mother received the hepatitis B vaccine series in 1998-1999. She reports
having several markers for lupus at this time.
6. A mother with a family history of immune disease, who was born in 1959, was
routinely vaccinated but "needed" and received a rubella booster shortly after
she delivered her first child, a girl, in 1987. This child is developmentally
normal and has received all recommended vaccines. After a miscarriage, the
patient delivered a boy in 1989. This child has significant speech difficulties;
he has received all recommended vaccines except hepatitis B. After a second
miscarriage, a boy was born in 1992 and was nursed for 18 months. He was
severely constipated but seemed to be developing normally. He was routinely
vaccinated, including the hepatitis B series in infancy, an MMR vaccine at age
12 months, and a monovalent measles vaccine at 61 months of age. Between 12 and
15 months of age, he lost eye contact and the few words he had acquired. He has
been diagnosed with autism.
All six of these mothers above, and many others like them, remained
rubella-susceptible following vaccination. Their postpartum revaccination did
not always result in immunity, and was followed by problems with their own
health and that of their children.
Results
A total of 60 respondents received MMR (32) or monovalent rubella vaccine (28)
postpartum. In 45 cases (75%), children born to these women have been diagnosed
with autistic spectrum disorder (ASD). In another 10 cases (17%), there is a
child with autistic behaviors, developmental delays, or ADD. Some of these
children have been diagnosed on the spectrum since the mothers initial response.
Four other women (7%) had children with other medical problems: endocrine,
allergic or immunologic with associated frequent infections. One mother in this
group had a normal child, an only daughter who was not breast-fed.
In 21 cases, the child born just prior to the revaccination has been diagnosed
on the autism spectrum. In 22 cases, a subsequent child born to these women has
been diagnosed. One mother has children on the spectrum from both the pregnancy
followed by the vaccine and the next pregnancy. There were 3 cases in which a
third pregnancy (the second subsequent to revaccination) produced a child who
became autistic. There are also many cases in which siblings of the autistic
children have been diagnosed with ADD/ADHD, other developmental delays, or other
medical problems.
The data are inconclusive on the relationship between breastfeeding and the
subsequent diagnosis of ASD. Among the children resulting from the pregnancy
followed by vaccination, at least 27 were breast-fed for varying lengths of
time. Of these, 17 (63%) became autistic. However, at least two children born
just before maternal revaccination developed autism although they were never
breast-fed. In one case a male child who was not breast-fed is severely affected
on the autism spectrum, has very elevated rubella and measles titers, and has
tested positive for Myelin Basic Protein antibodies. There were also cases in
which children with autism resulting from subsequent pregnancies were not
breast-fed.
No correlation was apparent between the type of vaccine given to the mother (MMR
or rubella) and the outcome for the child. Among the children born just prior to
revaccination, 13 (41%) of the children born to the women who received the MMR
became autistic, and eight (29%) of the children born to women given the rubella
vaccine were later diagnosed.
Twelve mothers in this study reported that their autistic children began to
display symptoms after receiving their MMR vaccination. Two mothers reported
that their children had symptoms of ASD prior to MMR vaccination, but that their
symptoms worsened after receiving the vaccine. Only one mother reported that her
third child (the second after her revaccination) was displaying significant
autistic symptoms prior to his own vaccination. Curiously, three separate
mothers reported that one of their children had reacted to DPT vaccination, but
none of these children have been diagnosed with ASD. (One boy with "cerebral
palsy" has classical behaviors associated with autism but has never been
diagnosed.)
Among the children born just prior to their mother's revaccination, the
diagnosis of ASD was highly correlated to gender (Table 1), with 49% of the
males, 13% females, and one of the two surviving gender-unknown children
resulting from the first pregnancy becoming autistic. These numbers include one
set of twins in which the male has been diagnosed on the spectrum and the female
required significant speech therapy.
The gender selection was also obvious among second children born to these
mothers: 69% of the males, 31% of the females (and one gender unknown child)
resulting from these pregnancies became autistic (Table 2). These numbers
include two sets of twin boys. In one set, both twins have typical autism, while
the other set includes one child with ASD and the other with other delays.
Tables 1 and 2 together include all the children of the 60 mothers, except those
born prior to the pregnancy followed immediately by vaccination.
Although the mothers' reactions were not a focus of this study, several mothers
reported reactions to MMR or rubella vaccine. Two women reported short-term
reactions such as fever and rash; four women reported joint pain/arthritis; and
three women reported other long-term health problems. Only two of the women who
noted their own reactions indicated that they had any health problems prior to
their revaccination. Six of the mothers in this study, who had no prior
obstetrical difficulties, reported having miscarriages after receiving the
postpartum vaccination. There were also two cases of difficult pregnancies, and
one case in which a woman carrying twins lost one of the children.
Discussion
Prospective studies to investigate problems with vaccines are not feasible in
the United States at the present time because of mandates. Retrospective studies
should include very large samples to be meaningful. This is extremely difficult
because of the need to identify and contact participants with no assurance of
response. The individual researcher is therefore left with the case presentation
approach to illustrate unusual and unexpected outcomes. These cases are
self-selected women who read materials that focus on suspected adverse effects
of vaccines.
The study design does not permit a calculation of the incidence of the severe
effects reported nor any comparison with their incidence in mothers who were not
revaccinated. However, even the rare occurrence of such severe effects following
postpartum vaccination warrants careful examination and a search for a possible
mechanism.
As is frequently stated, any risk from vaccines should be viewed in perspective
with the danger from vaccine-preventable disease. The prevention of Congenital
Rubella Syndrome (CRS) in future pregnancies is the main indication for
postpartum revaccination. Maternal rubella infection during the first trimester
of pregnancy may affect the fetus and result in the development of CRS, a
terrible complication which is manifested by somatic, developmental,
neurological, cardiac, and sensory defects and disorders.
Autism is not any less devastating a disease than CRS. It is also a lifetime
sentence of pain and suffering to the involved child and parents and an unending
burden on the community. If, in any way, maternal revaccination contributes to
the children's autism, then it is imperative that a complete and true disclosure
of the risks and benefits be made to the mother before she is revaccinated. A
review and definition of the present dangers and risks of CRS is therefore in
order.
Rubella and the CRS became nationally reportable diseases in 1966, and the CRS
is currently tracked through the National CRS Registry of the National
Immunization Program. In 1969, there was a large rubella outbreak with
approximately 57,686 cases. The rubella vaccine was licensed that year and has
been used ever since, singly or in the MMR. Since 1983, there have been fewer
than 1,000 cases of rubella per year nationwide except for two small outbreaks
in 1990 and 1991 in California and in Pennsylvania's Amish Country. Since 1992,
only around 200 cases of rubella are reported nationally every year. Except
during early pregnancy, rubella is a relatively mild disease.
There is no exact count of CRS cases prior to 1969, when the vaccine was
introduced in the United States. In 1970, there were 67 cases reported to the
registry, the largest number ever, in a single year. Since 1980, however, only
five to six cases of CRS on average have been reported each year, except during
the 1990 and 1991 outbreaks, when there were 25 and 33 cases. Only 9 cases of
CRS were reported in 1997. The mothers of all 9 infants were born in Latin
America or the Caribbean.(2) The recommendation to revaccinate
rubella-susceptible women was issued in 1977. There were only 22 cases of CRS
nationwide the year before.
The administration of rubella (and MMR) vaccine in the postpartum period is
convenient for the medical practitioners, and little consideration is given to
the viral transmission between the mother and her infant child.
Although vaccine virus may be isolated from the pharynx, vaccinees do not
transmit rubella to others, except occasionally in the case of the vaccinated
breast-feeding woman. In this situation, the infant may be infected, presumably
through breast milk, and may develop a mild rash illness, but serious effects
have not been reported.(3)
Though the Physicians' Desk Reference states that "caution should be exercised"
when Meruvax II (or MMR II) is administered to a nursing mother,(4) not a single
woman in the study recalled being informed that such viral excretion occurred,
nor asked if she was planning future pregnancies.
While there have been no reports of possible viral transmission between mother
and child except via breast milk, the cases of two children in this study, who
were not breast-fed and developed autism, suggest that direct transmission may
occur.
It is not known whether measles and mumps viruses are excreted in breast milk,
but a report in the veterinary literature seems to suggest that the canine
distemper virus, a morbillivirus closely related to the measles virus, may have
caused distemper in nursing pups.(5)
Is there a mechanism that could account for the induction of autism in children
of these sixty mothers? Comi and coworkers6 have reported a higher incidence of
autism in families with immune disorders. They also found that the more immune
defects in a family, the higher the incidence of autism, and that a mother who
has an immune disease has a nine-fold increased chance to have a child with
autism.
The failure of certain women to develop or maintain protective antibodies after
immunization may be an expression of an immune defect, which may predispose
their children to autism. This risk may increase if the mothers are given added
vaccines or if the children are exposed to early, combined, or severe antigenic
insults, namely their own immunizations. Preser-vatives in some vaccines may
also contribute to further toxic and immune injury and lead to more damage.(7)
Others have adduced evidence of the immunological aspects of autism. Notably,
Dr. Vijendra Singh has made a compelling argument for autism being considered an
autoimmune disorder.(8) The mechanism by which a developing brain might be
affected would likely be an immune response resulting in antibodies against the
brain or neurological tissue. It has been theorized that certain viruses may
induce this autoimmune response. Evidence of antibodies to Myelin Basic Protein
(MBP),(9) neuron-axon filament proteins,(10) and serotonin receptors(11) have
been found in autistic children. More specifically, Dr. Singh and his colleagues
have also found that measles virus and human herpesvirus-6 viral antibody levels
were higher in the blood of autistic children, and that they often co-occurred
with brain autoantibodies. They found a 90% correlation between the presence of
measles-IgG-positive sera and MBP autoantibodies, which confirms reports from
parents, including at least one family in this study. This relationship between
measles antibodies and MBP is particularly troubling in light of parental
reports that their children became autistic following their MMR vaccination.
Recent research has also shown live vaccine strain measles virus in the
intestines of autistic children.(12-14) It has also been found that the measles
virus (or vaccine) can cause immunosuppression.(15)
There have been no studies on the possibility of cumulative effects of a
mother's revaccination or the second generational effects on their children when
they are themselves vaccinated. The cases reported here suggest cause for
concern.
The mothers in this study were also adversely affected by their revaccination in
some cases. The reports of joint problems and arthritis are not surprising as
rubella vaccination has been linked to arthritis in several studies.(16-18)
However, the reports of miscarriages and difficult pregnancies, reported here
for the first time, were unexpected and alarming. As we have no theory to
explain this finding, further study is clearly needed in this area.
Recommendations
In the light of the information obtained through this study and the supportive
findings of other researchers, we make the following recommendations:
1. The routine administration of a live virus vaccine booster, during the
postpartum period, to previously vaccinated women who have remained
rubella-susceptible, should be reconsidered. The present minute risk of CRS does
not justify revaccination of women at such a critical time. Indeed, the same
caution should be exercised in the case of all women who have failed to produce
or maintain adequate protective titers after vaccination.
2. When obtaining "informed consent," medical practitioners should clearly
explain to mothers that it is known that the rubella virus from vaccine may be
excreted in their nose, throat, and breast milk.
3. Further research into the possibility of viral transmission through close
contact between a mother and infant child should be done.
4. The excretion of the measles virus from vaccine in breast milk should be
investigated.
5. Whether "routine" hepatitis B vaccination in the newborn period is an
antigenic insult which increases the risk of developing autism should be
examined.
6. Early and combined frequent vaccinations of children should be reviewed.
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F. Edward Yazbak, MD, FAAP, and Kathy L. Lang-Radosh, MS, TL Autism Research,
West Falmouth, MA, E-mail: TLAutStudy@aol.com.
This article was originally published in the Medical Sentinel 2001.