http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15056235

Pediatr Int. 2004 Apr;46(2):122-5.  Related Articles,Links 

Failure of inactivated influenza A vaccine to protect healthy children aged 6-24 months.

Maeda T, Shintani Y, Nakano K, Terashima K, Yamada Y.

Department of Pediatrics, Public Shisou General Hospital, Shisou, Japan.

Abstract Background: The efficacy of inactivated influenza vaccine in healthy
infants and children younger than 24 months has not been confirmed. The aim
of the present study was to determine the prophylactic effect of inactivated
influenza vaccine against influenza A in healthy children aged 6-24 months.
Methods: Healthy infants and young children (6-24 months old) were
immunized by
subcutaneous injection of inactivated influenza vaccine before influenza
seasons. Age matched children were randomly assigned as the control. These
children
were followed up from January to April in each year (2000, 2001 and 2002).
The
attack rates of influenza A infection was compared and statistically
assessed.
Results: The attack rate of influenza A virus infection in the vaccine group
and the control group were 14.8% (n = 27) vs 12.5% (n = 32) in 2000 (P =
0.526); 2.8% (n = 72) vs 7.2% (n = 69) in 2001 (P = 0.203); and 3.4% (n =
52) vs
8.9% (n = 56) in 2002 (P = 0.205). The attack rates of influenza A between
the
two groups were not significantly different. Conclusion: Inactivated
influenza
vaccine did not reduce the attack rate of influenza A infection in 6-24 month
old children.

PMID: 15056235 [PubMed - in process]