EDUCATION AND BOARD CERTIFICATIONS

1. Human Pathology, Toxicology, Immunology, and Biochmestry

Ph.D. 1989 Comparative Pathology. University of California Davis, Davis, California.

Subject of studies: Human pathology, toxicology, pharmacology, medical immunology, medical biochemistry, analytical toxicology, environmental toxicology, and experimental toxicology.

Dissertation: Toxicokinetics and Toxicity of Vanadate

DABT 1994 Diplomate, American Board of Toxicology

II. Veterinary Pathology, Toxicology, Immunology, and Endocrinology

DABVT 1996 Diplomate, American Board of Veterinary Toxicology

M.V.Sc. 1978 Veterinary sciences. University of Cairo, College of

Veterinary Medicine, Cairo, Egypt

Subject of studies: Veterinary pathology and physiology.

Dissertation: Histopathological and histochemical changes in the adrenal glands of the Egyptian Buffalo with follicular cysts and inactive ovaries.

BVMS 1975 University of Baghdad, College of Veterinary Medicine,

Baghdad, Iraq.

Personal Information

United States Citizen

Languages: English and Arabic: speak, read, and write fluently

• Expertise in human, veterinary, experimental, and environmental toxicology and pathology, including: diagnostic toxicology (exposure of human and animals to pesticides, herbicides, heavy metals, organic solvents, biotoxins, therapeutic drugs, industrial chemicals, and radiation), evaluating human and veterinary clinical data and pathological lesions in tissues, and experience in the kinetics of toxicants in human and animals.

• Worked with various communities and health care providers to identify causes of illness resulting from environmental exposure to pesticides, herbicides and other xenobiotics, and medications.
• Expertise in writing medical opinions in support of legal claims and obtaining a proper diagnosis in cases related to exposure of people and animals to toxic agents, therapeutic drugs, and radiation.
• Served as Expert Witness on many cases involving the exposure of people to chemicals at workplace. In these cases, I identified the cause(s) of illnesses and provided the treating physicians and the attorneys with reports describing my findings.

• Over 15 years experience of directing, designing, and implementing in vivo and in vitro toxicological studies according to Good Laboratory Practice Guidelines. Wrote protocols, standard operating procedures, and quality assurance plan for toxicity and toxicokinetic studies. Developed methods to evaluate the effects of toxicants and drugs on biological systems (in vitro and in vivo systems).

• Developed protocols for and interpreted results of Gas Chromatography and High Performance Liquid Chromatography, Liquid Scintillation Counter and Radiomatic Detector, Spectrophotometer (UV-Visible), Biological Sample Oxidizer, and other analytical systems.

• Performed Enzyme assays in serum and tissues.
• Perform assays in serum and tissues to measure heavy metals and pesticides.
• Used radioisotopes (¹⁴C, ³H, ³²P, and others) to study drugs and xenobiotics metabolism in vivo and/or in vitro.
• Collected, inspected, and analyzed numerical data derived from experimental studies.

• Instructed and supervised undergraduate, graduate students, laboratory assistants, and laboratory technicians in the areas of general toxicology, systemic toxicology, toxicologic pathology, analytical toxicology.

WRITING RESEARCH GRANTS AND CONTRACTS AND SUPERVISING EXPERIENCE

• Served as Principal and Co-Principal Investigator in many funded studies using animal models to evaluate the toxicokinetics and the toxicity of xenobiotics, pesticides and drugs. Maintain budgets, write budget reports and keep projects running within the predicted time frames. Supervised research activities in toxicology facilities for about 15 years. The following is a list of previously funded projects

• Project Title: Quantitative Evaluation of Serum Chemistry, Hematology and Pathological Parameters in Dog, Sheep, and Pig Exposed To Whole Body Irradiation.

Agency: AMGEN Pharmaceutical Inc. Thousand Oaks, CA 91320

Duration: 30 months (1993-1995)

Amount: $254,778, Position: PI

• Project Title: Improved Models of Risk for Exposure to Organic Toxicant and Carcinogens.

Agency: United States Environmental Protection Agency

Duration:48 months (1990-1995)

Amount: $980,000

Project Role: Co-PI

• Project Title: Improved Models of Risk for Exposure to Organic Toxicant.

Agency: United States Environmental Protection Agency

Duration:36 months (1987-1990)

Amount: $240,000

Project Role: Co-PI

• Project Title: Dermal Absorption of Methanol and Gasoline/Methanol Mixtures.

Agency: California Air Resources Board

Duration:18 months (7/90-12/91)

Amount:$84,000

Project Role: Co-PI

• Project Title: Toxicity of the Inhaled Dimethylselenide in Adult Rat.

Agency: University of California, Riverside

Duration: 12 months (07/87-07/88)

Amount: $70,000

Position: Co-PI

 

• Project Title: Inhalation Uptake of Xenobiotic Vapors in People.

Agency: California Air Resources Board; Contract No. A5-155-33

Duration: 18 months (1986-1987)

Amount: $150,000

Position: Investigator

• Project Title: Effects of Airborne Particulate Matter.

Agency: California Air Resources Board; Contract No. A4-133-33

Duration: 24 months (1985-1987)

Amount: $250,000

Position: Investigator

• Project Title: Gastrointestinal Tract Uptake of Benzene in Drinking Water, and Consequent Tissue and Fetal Retention.

Agency: Toxic Substance Research and Teaching Program, University of California, Davis

Duration: 12 months (1986-1987)

Amount: $50,000

Position: Co-PI

• Project Title: Inhalation Uptake of Xenobiotic Vapors at Trace Levels.

Agency: California Air Resources Board; Contract No. A3-132-33

Duration: 18 months (1984-1986)

Amount: $140,000

Position: Investigator

• Project Title: Toxicity and Toxicokinetics of Vanadium in Rodents.

Agency: United States Department of Energy

Duration: 72 months (1981-1987)

Position: Co-PI

• Project Title: Studies of Biological Behavior of Pu-241 and Am-241 in Rat, Dog, and Primate.

Agency: United States Department of Energy

Duration: 72 months (1980-1986)

Position: Investigator

• Project Title: Respiratory Tract Deposition of Inhaled Aerosols in Small Rodents.

Agency: United States Environmental Protection Agency

Duration: 60 months (1980-1985)

Amount:$500,000

Position: Investigator

 

1996-June, 1997 Toxicology Information Specialist and Outreach Coordinator, Center for Environmental Health Sciences.

University of California Davis, Davis, CA 95616

1991-1996 Assistant Research Toxicologist.

Institute of Toxicology & Environmental Health

University of California Davis, Davis, CA 95616

1991-1996 Member of Review Board

Bulletin of Environmental Contamination and

Toxicology.

1991-1992 Served as faculty advisor for 72 undergraduate students of various academic disciplines. (5-10 hours per week)

University of California Davis, Davis, CA 95616

Institute of Toxicology & Environmental Health

University of California Davis, Davis, CA 95616

1979-1986 Staff Research Associate II, Toxicologist

Institute of Toxicology and Environmental Health

University of California Davis, Davis, CA 95616

• Society of Toxicology
• American Board of Toxicology
• American Board of Veterinary Toxicology
• American Association for the Advancement of Science
• American Chemical Society
• American Lung Association
• Editorial Board, Bulletin of Environmental Contamination and Toxicology

I. Articles:

1982 Wei, C. I., M. A. Al-Bayati, M. R. Culbertson, L. S. Rosenblatt, and L. D.

Hansen. Acute toxicity of ammonium metavanadate in mice. Journal of Toxicology and Environmental Health 10: 673-687.

1984 Raabe, O. G., M. A. Al-Bayati, F. Gielow, J. P. Schreider, and N. J.Parks. Studies

of the distribution in beagles of Pu-241 after intratracheal instillation of ultrafine insoluble particles. Health Physics 47:210.

1987 Knaak, J. B., J. Schreider, O. G. Raabe, M. A.Al-Bayati and B. W. Wilson. The

percutaneous absorption of oxidazan in the adult female rat. In: Pesticide Science and Biotechnology. Greenhalgn, R. and Roberts, T. R. (eds.), Blackwell Scientific Publications, pp. 545-548.

1987 Knaak, J. B., M. A. Al-Bayati, F. Gielow, and O. G. Raabe. Safety related to

exposure: Dermal dose-red cell cholinesterase response curves for Ethoprop and Mocap 6 EC. Bulletin of Environmental Contamination Toxicology 38: 834-839, Springer-Verlag New York Inc.

l988 Raabe, O. G., M. A. Al-Bayati, S. Teague, and A. Rasolt. Regional deposition of

inhaled monodisperse coarse and fine particles in small laboratory animals. Annals of Occupational Hygiene 32(1): 53-63.

1989 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, J. L. Wiedmann, J. W. Pensyl, J. H. Ross, A. P. Leber, and P. Jones. Mixer-loader-applicator exposure and percutaneous absorption studies involving EPTC herbicide. Chapter 22. In: Biological Monitoring for Pesticide Exposure: Measurement, Estimation,and Risk Reduction, Wang, R. G. M., C. A. Franklin, R. C. Honeycut, and J. C. Reinert (eds.), American Chemical Society, Washington, DC., pp. 288-303.

1989 Al-Bayati, M. A., S. N. Giri, O. G. Raabe, L. S. Rosenblatt, and M. Shifrine. Time and dose-response study of the effects of vanadate on rats: Morphological and Biochemical changes in organs. Journal of Environmental Pathology, Toxicology and Oncology 9(5): 435-455.

1990 Al-Bayati, M. A., S. N. Giri and O. G. Raabe. Time and dose-response study of the effects of vanadate on rats: Changes in blood cells and serum elements. Journal of Environmental Pathology, Toxicology, and Oncology 10(4-5): 206-213.

1990 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, and J. N. Blancato. In vivo percutaneous absorption studies in rat: Pharmacokinetics and modeling of isofenphos absorption. In: Prediction of Percutaneous Penetration: Methods, Measurements, and Modelling. Scott, R. C. (ed), IBC Technical, England.

1991 Al-Bayati, M. A., O. G. Raabe, S. N. Giri, and J. B. Knaak. Distribution of vanadate in rat following subcutaneous and oral exposure. Journal of the American College of Toxicology 10(2): 233-241.

1992 Al-Bayati, M. A., M. R. Culbertson, J. P. Schreider, L. S. Rosenblatt, and O. G. Raabe. The lymphotoxic action of vanadate. Journal of Environmental Pathology, Toxicology, and Oncology, Volume II, No.2.

1992 Knaak, J. B., M. A. Al-Bayati and O. G. Raabe. Physiologically-based pharmacokinetics modeling to predict tissue dose and cholinesterase inhibition in workers exposed to organophosphorus and carbamate pesticides. In: Health Risk Assessment Through Dermal and Inhalation Exposure and Absorption of Toxicant, G.M. Wang, J.B. Knaak, and HI Maibach (eds.). CRC Press, Boca Raton, FL.

1992 Mohammed A. Al-Bayati, Otto G. Raabe, and Stephen V. Teague. Effect of inhaled dimethylselenide in the Fischer 344 male rat. Journal of Toxicology and Environmental Health 37:549-557.

1993 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, J.N. Blancato. Development of

in vitro V_max and K_m Values for the metabolism of isofenphos by P-450 liver enzymes in animals and human. Toxicology and Applied Pharmacology 120:106-113.

1993 Sidney M. Gospe, Jr. and Al-Bayati, M. A. Comparison of oral and inhalation exposures to toluene. American College of Toxicology, 13(1): 21-32.

1994 Raabe, O. G., D. W. Wilson, M. A. Al-Bayati, W. J. Hornof and L. S. Rosenblatt. Biological effects of inhaled pollutant aerosols. Ann. Occup. Hyg. Vol. 38 Supplement 1. pp. 323-330.

 

1994 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, and J. N. Blancato. Prediction of anticholinesterase activity and urinary metabolites of isofenphos: Use of apercutaneous physiologically based pharmacokinetic-physiologically based pharmacodynamic model. In: Biomarkers of Human Exposure to Pesticides, Chapter 17, Saleh, MA, Blancato, JN, and Nauman, CH (eds.). American Chemical Society Symposium Series 542, Washington, D.C.

1995 Knaak, J. B., M. A. Al-Bayati, and O. G. Raabe. Development of partition coefficients, Vmax and Km values, and allometric relationships. Toxicology letters 79, 87-98.

1995 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, and J. N. Blancato. Use of a multiple pathway and multiroute PBPK model for predicting OP toxicity: In American Chemical Society Symposium: Field Application of Biomarkers for Agrochemicals. April 3-7, Anaheim, CA.

1996 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, and J. N. Blancato. Use of a multiple pathway and multiroute PBPK model for predicting OP toxicity: Field Application of Biomarkers for Agrochemicals. In American Chemical Society Symposium Series 643, Washington, D.C., pp.206-228

1996 Raabe, O.G. and Al-Bayati, M.A. Distribution and retention of inhaled vanadium on inert airborne particles. Ann. Occup. Hyg., Vol.41, supplement 1.

1999. Mohammed Ali Al-Bayati. Get All The Facts: HIV Does Not Cause AIDS. Toxi-Health International, Dixon, CA [ISBN 0-9673536-0-2]

2002. Mohammed Ali Al-Bayati. HIV Does Not Cause AIDS, letter to the editor of The British

Medical Journal. January 30, 2002 ( http://bmj.com/cgi/eletters/324/7331/237 ).

2002. Al-Bayati, MA. AIDS in Africa is Caused by Starvation and Medications. The British Medical Journal, March 7,

2002 [ http://bmj.com/cgi/eletters/324/7335/446/a#20389    ].

2002. Al-Bayati, MA. Keep The Dentist Working: HIV Does Not Cause AIDS. The British Medical March 15, 2002

[ http://bmj.com/cgi/eletters/324/7337/564#20541 ].

2002. Al-Bayati, MA. Stop Giving People Toxic Drugs: HIV Does Not Cause AIDS. The British Medical April 4, 2002

[ http://bmj.com/cgi/content/full/324/7340/757#responses ]

2002 Mohammed Ali Al-Bayati, Yan Xie, F. Charles Mohr, solomon B. Margolin, Shri

N. Giri. Effect of Pirfenidone Aganist Vanadate-Induced Kidney Fibrosis in Rats.

Biochemical Pharmacology ( In Press).

III. Reports:

1987 Raabe and Al-Bayati, M.A. Gastrointetinal-tract Uptake of Benzene in drinking water in rats. Submitted to the University of California Toxic Substance and Teaching Program, Davis, CA.

1988 Raabe, O.G. Knaak, J.B. , Al-Bayati, M.A., Uyeminami, D., and Gielow, F. Development of Multiple Route Compound Pharmacokinetic Models: Development of a physiological Pharmacokinetic Model for an Organophosphate: isofenphos. Submitted to Exposure Assessment group, USEPA, Wahington, DC. September 20, 1988.

1988 Raabe, O.G., Al-Bayati, M.A., Gielow, F., Teague, S., and Uyeminami. Inhalation Uptake of Xenobiotic Vapors by People. Submitted to the Biological effects Research Section, California Air Resources Board, SACRAMENTO, California (CARB Contract NO. A5-155-33). March 1988.

1992 Raabe, O.G., Al-Bayati, M.A., Shulec, P.D., Gielow, F., Uyeminami, and N. Shimasaki. Dermal Absorption of Methanol and methanol/Gasoline Mixtures. Submitted to the Biological effects Research Section, california Air Resources Board, Sacramento, California (CARB Contract NO. A933-186). December 1992.

1978. Shehata, H. A., A. A. Hegazy, and M. A. Al-Bayati. Histopathological and

histochemical studies in adrenal gland of buffalo in case of cystic and inactive ovaries.

X World Congress of Buiatrics, Aug. 16-19. Mexico.

1984 Raabe, O. G., M. A. Al-Bayati, F. Gielow, J. P. Schreider, and N. J.Parks. Studies of the distribution in beagles after intratracheal instillation as ultrafine insoluble particles. Presented at the Health Physics Society Annual Meeting, June. New Orleans, LA.

1985 Raabe, O. G., M. A. Al-Bayati, and F. Gielow. Metabolism of Pu-241 in beagles and non-human primates after intratracheal instillation of ultrafine insoluble particles. Presented at the Health Physics Society Annual Meeting, May. Chicago, IL,.

1988 Al-Bayati, M. A., S. N. Giri, O. G. Raabe, M. Shifrine, and L. S.Rosenblatt. Chronic renal toxicity of vanadium in rat. FASEB Meeting , May 1. Las Vegas, Nevada, USA,.

1988 Knaak, J. B., M. A. Al-Bayati, and O. G. Raabe. Study on the pharmacokinetics and toxicity of isofenphos in rat. FASEB Meeting, May 1. Las Vegas, Nevada, USA,.

1990 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, and J. N. Blancato. In vitro metabolism of isofenphos by human and animal liver. American Chemical Society Meeting, April 22-27. Boston, MA.

1992 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, and J. N. Blancato. Prediction of anticholinesterase activity and urinary metabolites of isofenphos: Use of a percutaneous physiologically based pharmacokinetic- physiologically based pharmacodynamic model. American Chemical Society Meeting, August 23-28. Washington, D.C.

1993 Knaak, J. B., M. A. Al-Bayati, O. G. Raabe, and J. N. Blancato. Development of

in vitro V_max and K_m values for the metabolism of isofenphos by P-450 liver enzymes in animals and human. Society of Toxicology 32nd Annual Meeting, March 14-18, New Orleans, Louisiana.

1994 M. A. Al-Bayati, J.B. Knaak, O. G. Raabe, and J. N. Blancato. The effects of enzyme inducers and inhibitors on the metabolism of isofenphos by rat liver P450 enzymes. Society of Toxicology 33th Annual Meeting, March 13-18, Dallas, Texas.

1995. M. A. Al-Bayati, J.B. Knaak, O. G. Raabe, and J. N. Blancato. Toxicity and

Pharmacokinetics of Isofenphos in Male Guinea Pig. Society of Toxicology 34th Annual Meeting, March 5-9. Baltimore, Maryland.

Induced Kidney Fibrosis by Pirfenidone in Rats. Society of Toxicology 40 th

AnnualMeeting, March 25-30. San Francisco, California.