<!DOCTYPE HTML PUBLIC "html.dtd"> <HTML> <HEAD> <TITLE>The Avalon Project : Statement of Jeffery P. Koplan, M.D., M.P.H. Director, Centers for Disease Control and Prevention U.S. Department of Health and Human Services Before the Committee on Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies United States Senate; October 23, 2001</TITLE> <META CONTENT="foreign relations, international law, treaties, agreements, conventions, protocols, diplomacy" NAME="keywords"> <META CONTENT="Documents relating to the September 11, 2001 : Attack on America" NAME="description"> <LINK HREF="../css/site.css" REL="stylesheet" TYPE="text/css" W3MIRHREF="http://avalon.law.yale.edu/css/site.css"> </HEAD> <BODY> <DIV CLASS="HeaderContainer"> <UL CLASS="HeaderTopTools"> <LI CLASS="Search"> <TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0"> <FORM ID="form" TARGET="_blank" NAME="form" ACTION="http://www.google.com/u/yaleu" METHOD="get"> <INPUT NAME="domains" VALUE="yale.edu" TYPE="hidden"> <INPUT NAME="sitesearch" VALUE="avalon.law.yale.edu/" TYPE="hidden"> <TR> <TD><INPUT / ONBLUR="if (this.value==''){this.value='Search Avalon'}" ONFOCUS="if (this.value=='Search Avalon'){this.value=''}" NAME="q" VALUE="Search Avalon" CLASS="SiteSearchBox" TYPE="text" ALT="Search Avalon"></TD> <!-- <td><A HREF="javascript:this.form.submit();"><IMG / SRC="http://www.law.yale.edu/library/searchGo.gif" ALT="Begin Search"></A></TD>--> <TD><INPUT / CLASS="go" TYPE="image" SRC="http://www.law.yale.edu/library/searchGo.gif" STYLE="margin-left:5px;" ALT="Submit Search"></TD> </TR> </FORM> </TABLE> </LI> </UL> <IMG / W3MIRSRC="http://avalon.law.yale.edu/images/avalon_logo2.gif" SRC="../images/avalon_logo2.gif" ALT="Logo"></A> </DIV> <DIV CLASS="text-properties"> <DIV ALIGN="center"> <TABLE BORDER="1" CELLPADDING="5" CLASS="site-menu"> <TR> <TD><A HREF="../default.asp" W3MIRHREF="http://avalon.law.yale.edu/default.asp">Avalon Home</A></TD> <TD><A HREF="../subject_menus/major.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/major.asp">Document<BR> Collections</A></TD> <TD><A HREF="../subject_menus/ancient.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/ancient.asp">Ancient <BR>4000bce - 399</A></TD> <TD><A HREF="../subject_menus/medieval.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/medieval.asp">Medieval <BR>400 - 1399</A></TD> <TD><A HREF="../subject_menus/15th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/15th.asp">15<SUP>th</SUP> Century <BR>1400 - 1499</A></TD> <TD><A HREF="../subject_menus/16th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/16th.asp">16<SUP>th</SUP> Century <BR>1500 - 1599</A></TD> <TD><A HREF="../subject_menus/17th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/17th.asp">17<SUP>th</SUP> Century <BR>1600 - 1699</A></TD> <TD><A HREF="../subject_menus/18th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/18th.asp">18<SUP>th</SUP> Century <BR>1700 - 1799</A></TD> <TD><A HREF="../subject_menus/19th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/19th.asp">19<SUP>th</SUP> Century <BR>1800 - 1899</A></TD> <TD><A HREF="../subject_menus/20th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/20th.asp">20<SUP>th</SUP> Century <BR>1900 - 1999</A></TD> <TD><A HREF="../subject_menus/21st.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/21st.asp">21<SUP>st</SUP> Century <BR>2000 - </A></TD> </TR> </TABLE> </DIV> <DIV CLASS="document-title"> September 11, 2001 : Attack on America<BR>Statement of Jeffery P. Koplan, M.D., M.P.H. Director, Centers for Disease Control and Prevention U.S. Department of Health and Human Services Before the Committee on Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies United States Senate; October 23, 2001 </DIV> <BR><BR> <DIV CLASS="docsignatures"> Testimony<BR> Before the Committee on Appropriations<BR> Subcommittee on Labor, Health and Human Services, Education and Related Agencies<BR> United States Senate <BR> <BR> CDC's Public Health Response to the Threat of Bioterrorism <BR> <BR> Statement of<BR> Jeffery P. Koplan, M.D., M.P.H.<BR> Director,<BR> Centers for Disease Control and Prevention<BR> U.S. Department of Health and Human Services <BR> <BR> For Release on Delivery<BR> Expected at 9:00 am<BR> on Tuesday, October 23, 2001 <BR> <BR> <BR> <BR> --------------------------------------------------------------------------------<BR> </DIV> <P>Good morning, Mr. Chairman and Members of the Subcommittee. I am Dr. Jeffrey P. Koplan, Director, Centers for Disease Control and Prevention (CDC). Thank you for the invitation to update you on CDC's public health response to the threat of bioterrorism. I will update you on CDC's response to recent anthrax exposures, and I will discuss the status of implementing the overall goals of our bioterrorism preparedness program. </P> <P>As has been highlighted recently, increased vigilance and preparedness for unexplained illnesses and injuries are an essential part of the public health effort to protect the American people against bioterrorism. Prior to the September 11th attack on the United States, CDC was making substantial progress toward defining, developing, and implementing a nationwide public health response network to increase the capacity of public health officials at all levelsfederal, state, and localto prepare for and respond to deliberate attacks on the health of our citizens. The events of September 11th were a defining moment for all of us, and since then we have dramatically increased our levels of preparedness and are implementing plans to increase it even further. </P> <H3>Recent Anthrax Exposures</H3> <P>As you are aware, many facilities in communities around the country have received anthrax threat letters. Most were received as empty envelopes; some have contained powdery substances. Moreover, in a few cases, actual anthrax exposures have occurred. On Wednesday, October 3rd, the Florida Department of Health notified CDC of a positive anthrax laboratory test result in a Florida resident who had recently visited North Carolina. Samples were sent overnight to CDC for confirmatory testing, and CDC dispatched two investigative teamsto Florida and North Carolinathe next day. By Sunday, October 7th, test results confirmed that a second persona coworker of the first individualhad been exposed to anthrax and that traces of the bacteria had been found in the workplace. A decision was made to close the building, and additional CDC staff were sent to help manage notification, health evaluations of other coworkers, and provision of prophylactic antibiotics after the National Pharmaceutical Stockpile was deployed. </P> <P>As CDC was continuing to receive clinical specimens and environmental samples from Florida, we became aware of a possible case of cutaneous anthrax in New York City. This person, an NBC employee in Rockefeller Plaza, had received an envelope containing powder on September 25th. The diagnosis was confirmed by immunohistochemistry on a skin biopsy specimen in CDC's laboratory in the early morning of October 12th, and the New York City Health Department and CDC immediately implemented appropriate public health actions, including restricting activity on two floors of 30 Rockefeller Plaza and evaluating workers for the need for prophylactic therapy. CDC sent additional investigative personnel to New York, joining the more than 30 epidemiologists and other CDC staff assisting with worker injury and enhanced syndrome surveillance following the September 11th terrorist attack. Laboratory studies on the powder from the September 25th letter were negative for the organism causing anthrax. Subsequent investigation identified a second letter that arrived on September 18th, which was found to be contaminated with Bacillus anthracis, the organism that causes anthrax. </P> <P>Last week, on October 15th, CDC was notified of a possible anthrax exposure on Capitol Hill. A letter, which has now been confirmed to have contained B. anthracis, was opened by a Senate staff member. This person took appropriate action, notifying emergency personnel, and Capitol, local, and federal emergency workers immediately implemented public health measures. Certain areas of the office building were closed, and employees were screened by history for exposure and started on antibiotic prophylaxis after a nasal swab was obtained for epidemiologic purposes. CDC sent two teams of epidemiologists to assist local, state, and federal authorities in the investigation. </P> <P>The best defense against such biologic threats continues to be accurate information regarding how to recognize a potential threat and knowledge of appropriate actions. In the Morbidity and Mortality Weekly Report (MMWR) and in multiple health advisories distributed via the Health Alert Network, CDC has issued several updates on the investigations as well as interim guidelines for state health departments with recommended procedures for handling such incidents. These guidelines include advice to the public and state and local health officials dealing with suspicious incidents, as well as guidance to clinical laboratory personnel in recognizing Bacillus anthracis in a clinical specimen. The guidelines also outline post-exposure prophylaxis recommendations. In persons exposed to Bacillus anthracis, disease can be prevented with antibiotic treatment. Early antibiotic treatment of all forms of anthrax is essential. Bacillus anthracis usually is susceptible to penicillin, doxycycline, and fluoroquinolones; but for bioterrorism planning, ciprofloxacin or doxycycline is recommended as the antibiotic for initial use for prophylaxis. Copies of the October 19, 2001, MMWR, which addresses these issues, have been provided to the Subcommittee. </P> <P>In collaboration with state and local health and law enforcement officials, CDC and the FBI are continuing to conduct investigations related to anthrax exposures. During this heightened surveillance, cases of illness that may reasonably resemble symptoms of anthrax will be thoroughly reviewed until anthrax can be ruled out. The public health and medical communities continue to be on a heightened level of disease monitoring to ensure that any potential exposure is recognized and that appropriate medical evaluations are given. This is an example of the disease monitoring system in action, and that system is working. </P> <P>As of noon October 22nd, 2 cases of inhalational anthrax have been identified in Florida, 2 cases of inhalational anthrax have been identified in Washington, DC, 5 cases of cutaneous anthrax have been identified in New York City, and 3 cases of cutaneous anthrax have been identified in New Jersey. </P> <H3>Public Health Leadership</H3> <P>The Department of Health and Human Services' (HHS) anti-bioterrorism efforts are focused on improving the nation's public health surveillance network to quickly detect and identify the biological agent that has been released; strengthening the capacities for medical response, especially at the local level; expanding the stockpile of pharmaceuticals for use if needed; expanding research on disease agents that might be released, rapid methods for identifying biological agents, and improved treatments and vaccines; and preventing bioterrorism by regulation of the shipment of hazardous biological agents or toxins. </P> <P>As the nation's disease prevention and control agency, it is CDC's responsibility on behalf of DHHS to provide national leadership in the public health and medical communities in a concerted effort to detect, diagnose, respond to, and prevent illnesses, including those that occur as a result of a deliberate release of biological agents. This task is an integral part of CDC's overall mission to monitor and protect the health of the U.S. population. </P> <P>In 1998, CDC issued Preventing Emerging Infectious Diseases: A Strategy for the 21st Century, which describes CDC's plan for combating today's emerging diseases and preventing those of tomorrow. It focuses on four goals, each of which has direct relevance to preparedness for bioterrorism: disease surveillance and outbreak response; applied research to identify risk factors for disease and to develop diagnostic tests, drugs, vaccines, and surveillance tools; infrastructure and training; and disease prevention and control. This plan was developed with input from state and local health departments, disease experts, and partner organizations such as the American Society for Microbiology, the Association of Public Health Laboratories, the Council of State and Territorial Epidemiologists, and the Infectious Disease Society of America. It emphasizes the need to be prepared for the unexpected whether it is a naturally occurring influenza pandemic or the deliberate release of smallpox by a terrorist. It is within the context of these overall goals that CDC has begun to address preparing our nation's public health infrastructure to respond to acts of biological terrorism. Copies of this CDC plan have been provided previously to the Subcommittee. In addition, CDC presented in March a report to the Senate entitled Public Health's Infrastructure: A Status Report. Recommendations in this report complement the strategies outlined for emerging infectious diseases and preparedness and response to bioterrorism. These recommendations include training of the public health workforce, strengthening of data and communications systems, and improving the public health systems at the state and local level. </P> <H3>CDC's Strategic Plan for Bioterrorism</H3> <P>CDC outlined necessary steps for strengthening public health and healthcare capacity to protect the nation against bioterrorist threats in its April 21, 2001, MMWR release of Biological and Chemical Terrorism: Strategic Plan for Preparedness and Response - Recommendations of the CDC Strategic Planning Workgroup. This report reinforces the work CDC has been contributing to this effort since 1998 and lays a framework from which to enhance public health infrastructure. In keeping with the message of this report, five key focus areas have been identified which provide the foundation for local, state, and federal planning efforts: Preparedness and Prevention, Detection and Surveillance, Diagnosis and Characterization of Biological and Chemical Agents, Response, and Communication. These areas capture the goals of CDC's Bioterrorism Preparedness and Response Program for general bioterrorism preparedness. </P> <DIV CLASS="docsignatures"> <DL> <DD><LI>Preparedness and Prevention</LI><BR><BR> <DD>CDC has been working to ensure that all levels of the public health community federal, state, and local are prepared to work in coordination with the medical and emergency response communities to address the public health consequences of biological and chemical terrorism. <BR><BR> <DD>CDC is creating diagnostic and epidemiological guidelines for state and local health departments and will help states conduct drills and exercises to assess local readiness for bioterrorism. In addition, CDC, the Food and Drug Administration (FDA), the National Institutes of Health (NIH), the Department of Defense (DOD), and other agencies are supporting and encouraging research to address scientific issues related to bioterrorism. In some cases, new vaccines, antitoxins, or innovative drug treatments need to be developed, manufactured, and/or stocked. Moreover, we need to learn more about the pathogenesis and epidemiology of the infectious diseases which do not affect the U.S. population currently. We have only limited knowledge about how artificial methods of dispersion may affect the infection rate, range of illness, and public health impact of these biological agents. <BR><BR> <DD><LI>Detection and Surveillance </LI><BR><BR> <DD>As was evidenced in Florida, New York, and Washington, DC, the initial detection of a biological terrorist attack occurs at the local level. Therefore, it is essential to educate and train members of the medical community both public and private who may be the first to examine and treat the victims. It is also necessary to upgrade the surveillance systems of state and local health departments, as well as within healthcare facilities such as hospitals, which will be relied upon to spot unusual patterns of disease occurrence and to identify any additional cases of illness. CDC is providing terrorism-related training to epidemiologists and laboratorians, infection control personnel, emergency responders, emergency department personnel and other front-line health-care providers, and health and safety personnel. CDC is providing educational materials regarding potential bioterrorism agents to the medical and public health communities on its website for Public Health Emergency Preparedness and Response at www.bt.cdc.gov. CDC is working with partners such as the Johns Hopkins Center for Civilian Biodefense Studies (www.hopkins-biodefense.org) and the Infectious Diseases Society of America to develop training and educational materials for incorporation into medical and public health graduate and post-graduate curricula. With public health partners, CDC is spearheading the development of the National Electronic Disease Surveillance System, which will facilitate automated, timely electronic capture of data from the healthcare system. <BR><BR> <DD><LI>Diagnosis and Characterization of Biological and Chemical Agents </LI><BR><BR> <DD>To ensure that prevention and treatment measures can be implemented quickly in the event of a biological or chemical terrorist attack, rapid diagnosis is critical. CDC has developed guidelines and quality assurance standards for the safe and secure collection, storage, transport, and processing of biologic and environmental samples. In collaboration with other federal and non-federal partners, CDC is co-sponsoring a series of training exercises for state public health laboratory personnel on requirements for the safe use, containment, and transport of dangerous biological agents and toxins. CDC, also in cooperation with the Association of Public Health Laboratories (APHL) and the National Laboratory Training Network (NLTN) have sponsored a "hands-on" laboratory course for public health microbiologists. In conjunction with the course, CDC produced two videos that were distributed to the participants as well as to members of the NLTN. The participants in this course are now using these videos and the other materials developed by CDC to train other laboratorians in their states. CDC is also enhancing its efforts to foster the safe design and operation of Biosafety Level 3 laboratories, which are required for handling many highly dangerous pathogens. Furthermore, CDC is developing a Rapid Toxic Screen to detect people's exposure to 150 chemical agents using blood or urine samples. <BR><BR> <DD><LI>Response </LI><BR><BR> <DD>A decisive and timely response to a biological terrorist event involves a fully documented and well rehearsed plan of detection, epidemiologic investigation, and medical treatment for affected persons, and the initiation of disease prevention measures to minimize illness, injury and death. CDC is addressing this by (1) assisting state and local health agencies in developing their plans for investigating and responding to unusual events and unexplained illnesses, and (2) bolstering CDC's capacities within the overall federal bioterrorism response effort. CDC is formalizing current draft plans for the notification and mobilization of personnel and laboratory resources in response to a bioterrorism emergency, as well as overall strategies for vaccination, and development and implementation of other potential outbreak control strategies such as quarantine measures. In addition, CDC is developing national standards to ensure that respirators used by first responders and by other health care providers responding to terrorist acts provide adequate protection against weapons of terrorism. <BR><BR> <DD><LI>Communication Systems </LI><BR><BR> <DD>Rapid and secure communications are crucial to ensure a prompt and coordinated response to an intentional release of a biological agent. Thus, strengthening communication among clinicians, emergency rooms, infection control practitioners, hospitals, pharmaceutical companies, and public health personnel is of paramount importance. To this end, CDC is making a significant investment in building the nation's public health communications infrastructure through the Health Alert Network (HAN). HAN is a nationwide program to establish the communications, information, distance-learning, and organizational infrastructure for a new level of defense against health threats, including bioterrorism. Currently, 13 states are connected to all of their local health jurisdictions; 37 states have begun connecting to local providers as well; and CDC is also directly connecting to groups, such as the American Medical Association, to cast a broad net of coverage. CDC has also established the Epidemic Information Exchange (Epi-X), a secure, Web-based communications system that provides information sharing capabilities to state and local health officials. CDC also provides timely satellite broadcast and web-broadcast training through the Public Health Training Network. For example, just last week, CDC experts shared information on anthrax with physicians, hospitals, and other healthcare providers across the country. <BR><BR> <DD>Ongoing communication of accurate and up-to-date information helps calm public fears and limit collateral effects of the attack. CDC communicates with the public directly through its website on emergency preparedness and through a public inquiry telephone and email system, which, since the recent attacks, has responded to hundreds of questions daily. In addition, CDC communicates to the public by releasing daily updates to the news media, answering inquiries from the press and providing medical experts for interviews. <BR><BR> </DL></DL> <H3>The National Pharmaceutical Stockpile </H3> <P>Another integral component of public health preparedness at CDC has been the development of a National Pharmaceutical Stockpile (NPS), which is mobilized in response to an episode caused by a biological or chemical agent. The role of the CDC's NPS program is to maintain a national repository of life-saving pharmaceuticals and medical material that can be delivered to the site or sites of a biological or chemical terrorism event in order to reduce morbidity and mortality in a civilian population. The NPS is a backup and means of support to state and local first responders, healthcare providers, and public health officials. The NPS program consists of a two-tier response: (1) 12-hour push packages, which are pre-assembled arrays of pharmaceuticals and medical supplies that can be delivered to the scene of a terrorism event within 12 hours of the federal decision to deploy the assets and that will make possible the treatment or prophylaxis of disease caused by a variety of threat agents; and (2) a Vendor-Managed Inventory (VMI) that can be tailored to a specific threat agent. Components of the VMI will arrive at the scene 24 to 36 hours after activation. The NPS was mobilized for the first time on September 11, when a 12-hour push pack was deployed to New York City, delivering 50 tons of medical supplies to the site of the disaster in 7 hours. In addition, substantial quantities of VMI were delivered to New York City within 24 hours. Components of the VMI were deployed to Palm Beach, Florida, this month to provide adequate supplies of ciprofloxacin to provide prophylaxis to individuals who were potentially exposed to anthrax. CDC has developed this program in collaboration with federal and private sector partners and with input from the states. </P> <H3>Core Capacities for State and Local Health Bioterrorism Preparedness and Response </H3> <P>CDC has been working with partners at all levels to develop core capacities needed to respond to pubic health threats and emergencies. CDC is also developing specific guidelines to assist public health agencies in their efforts to build comprehensive bioterrorism preparedness and response programs. This collaborative effort engages federal, state, and local partners in determining what is needed for state and local public health agencies to improve their preparedness and response to bioterrorism. This process enables health departments to more effectively target specific improvements to protect the public's health in the event of a biological or chemical terrorist event and will provide the framework for future program efforts. The core capacities effort is for dual purpose. While these capacities focus on bioterrorism events, they are also relevant to naturally occurring infectious disease outbreaks and natural disasters. </P> <H3>Challenges </H3> <P>CDC has been addressing issues of detection, epidemiologic investigation, diagnostics, and enhanced infrastructure and communications as part of its overall bioterrorism preparedness strategies. Based on federal, state, and local response in the weeks following the events of September 11th, and on recent training experiences, such as the National TOPOFF event and the Dark Winter exercise, CDC has learned valuable lessons and identified gaps that exist in bioterrorism preparedness and response at federal, state, and local levels. CDC will continue to work with partners to address challenges such as improving coordination among other federal agencies during a response and understanding the necessary relationship needed between conducting a criminal investigation versus an epidemiologic case investigation. These issues, as well as overall preparedness planning at federal, state, and local levels, require additional action to ensure that the nation is fully prepared to respond to acts of biological and chemical terrorism. </P> <P>Disease experts at CDC are developing strategies to prevent the spread of disease during and after bioterrorist attacks. Specific components include (1) creating protocols for immunizing at-risk populations; (2) isolating large numbers of exposed individuals; (3) reducing occupational exposures; (4) assessing methods of safeguarding food and water from deliberate contamination; and (5) exploring ways to improve linkages between animal and human disease surveillance networks since threat agents that affect both humans and animals may first be detected in animals. </P> <H3>Conclusion </H3> <P>In conclusion, CDC is committed to working with other federal agencies and partners as well as state and local public health departments to ensure the health and medical care of our citizens. We have made substantial progress to date in enhancing the nation's capability to prepare for and respond to a bioterrorist event. The best public health strategy to protect the health of civilians against biological terrorism is the development, organization, and enhancement of public health prevention systems and tools. Priorities include strengthened public health laboratory capacity, increased surveillance and outbreak investigation capacity, and health communications, education, and training at the federal, state, and local levels. Not only will this approach ensure that we are prepared for deliberate bioterrorist threats, but it will also ensure that we will be able to recognize and control naturally occurring new or re-emerging infectious diseases. A strong and flexible public health infrastructure is the best defense against any disease outbreak. </P> <P>Thank you very much for your attention. </P> <BR><BR> <DIV ALIGN="center"> <TABLE CLASS="sourcetable"> <TR> <TD CLASS="sourcecell"> Source:<BR> U.S. Government Website<BR> </B></TD> </TABLE> </DIV> <BR> <DIV ALIGN="center"><TABLE BORDER="1" CELLPADDING="5"> <TR> <TD ALIGN="center"><B><A HREF="../subject_menus/sept_11.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/sept_11.asp">September 11 Page</A></B></TD> </TR> </TABLE> </DIV> <BR> <DIV ALIGN="center"> <TABLE BORDER="1" CELLPADDING="5" CLASS="site-menu"> <TR> <TD><A HREF="../default.asp" W3MIRHREF="http://avalon.law.yale.edu/default.asp">Avalon Home</A></TD> <TD><A HREF="../subject_menus/major.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/major.asp">Document<BR> Collections</A></TD> <TD><A HREF="../subject_menus/ancient.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/ancient.asp">Ancient <BR>4000bce - 399</A></TD> <TD><A HREF="../subject_menus/medieval.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/medieval.asp">Medieval <BR>400 - 1399</A></TD> <TD><A HREF="../subject_menus/15th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/15th.asp">15<SUP>th</SUP> Century <BR>1400 - 1499</A></TD> <TD><A HREF="../subject_menus/16th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/16th.asp">16<SUP>th</SUP> Century <BR>1500 - 1599</A></TD> <TD><A HREF="../subject_menus/17th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/17th.asp">17<SUP>th</SUP> Century <BR>1600 - 1699</A></TD> <TD><A HREF="../subject_menus/18th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/18th.asp">18<SUP>th</SUP> Century <BR>1700 - 1799</A></TD> <TD><A HREF="../subject_menus/19th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/19th.asp">19<SUP>th</SUP> Century <BR>1800 - 1899</A></TD> <TD><A HREF="../subject_menus/20th.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/20th.asp">20<SUP>th</SUP> Century <BR>1900 - 1999</A></TD> <TD><A HREF="../subject_menus/21st.asp" W3MIRHREF="http://avalon.law.yale.edu/subject_menus/21st.asp">21<SUP>st</SUP> Century <BR>2000 - </A></TD> </TR> </TABLE> </DIV> </DIV> <DIV ID="ContainerDefaults" CLASS="FooterContainer"> <DIV CLASS="Copyright">© 2008 Lillian Goldman Law Library</DIV> <DIV CLASS="ContactInfo">127 Wall Street, New Haven, CT 06511.</DIV> <UL CLASS="NavBottom"> <LI><A HREF="about/purpose.asp" W3MIRHREF="http://avalon.law.yale.edu/sept11/about/purpose.asp">Avalon Statement of Purpose</A></LI><LI><A HREF="http://www.law.yale.edu/library/3312.asp">Contact Us</A></LI><LI><A TARGET="_blank" HREF="http://library.law.yale.edu/">Yale Law Library</A></LI><LI><A TARGET="_blank" HREF="http://www.library.yale.edu/">University Library</A></LI><LI><A TARGET="_blank" HREF="http://www.law.yale.edu/">Yale Law School</A></LI><LI><A HREF="http://morris.law.yale.edu/">Search Morris</A></LI><LI><A TARGET="_blank" HREF="http://orbis.library.yale.edu/">Search Orbis</A></LI> </UL> </DIV> </BODY> </HTML>